'ākilikai phosphatase - he'ūhū peni mäka

Ma ka hana pono, clinicians i pinepineʻalo me ka ulia mahuahua i loko o kona'ākilikai phosphatase hope. Ma ke ano o ka nunui-ho'āʻo He poho no biochemical haʻawina ka mea, i ka manawa e kū i ka ha awina o ka'ūhū. E like me ke kiʻekiʻe o ka ha awina o ka la'ūhū hiki huai ae maʻi o ka hepatobiliary'ōnaehana a me ka iwi'aʻaʻa.

'ākilikai phosphatase - he'ūhū e pili ana i ka papa o hydrolases, hoopili aku i ka posapahate pae mai kekahi biopolymers (nā polokina, nukelea nāʻakika, alkaloids). Ka mea kiekie loa'ūhū ha awina i malama ia ma ka'ākilikai 'ia. Ke'ūhū ua ke aupuni 'o aeee pili me ka wai koko membranes o ka moku'āina, nolaila, e pili ana i kaʻili lahilahi-paa ai nā'ūhū. 'ākilikai phosphatase (Alp) ua haku o kaʻokoʻa isozymes mea i waihoia ma ka epithelium zhelchnovyvodnyh ducts plasmatic membranes o hepatocytes a me neurons, iwi, liʻiliʻi, keiki, hakuʻala.

Kau Activity o isoenzymes ma ka hoʻohana 'ana i electrophoresis. Eia naʻe, Alp isozymes mai ole i ka maopopo hui specificity, a me electrophoretic ki ina hana like ka loa paʻakikī. Nolaila, e Nohie noiʻi ka hoʻohana 'ana i kekahiʻano hana i ua ma muli o keʻano isoenzymes pā lonoaʻili i ka wela. Intestinal 'ākilikai phosphatase pili i thermostable hapa iki a me isozymes o ke ake a me ka iwi - he thermolabile. Most ikepili koʻikoʻi e hoʻa'ā i ka iwi phosphatase.

Lāʻau lapaʻau'ākilikai phosphatase mea i ka läÿau, o ka iwi a me ka akepaʻa isoenzymes. Release o'ūhū mai i ke koko i loko o kekahi mau nā'aʻaʻa hilinaʻi nui ma luna o ka physiological moku'āina a me ka makahiki o ka meaola (hāpai keiki, parturition, lactation pinepine '). I ka ha awina kiʻekiʻe o kona'ākilikai phosphatase i loko o ke koko o ka bipi kanaka mea ku pono i ka pili ana o ka osteoblasts ma ka iwi'aʻaʻa, a i ke kumu ma ka keʻano o ka hanaʻana o ka hana ka ulu ana o ka meaola. I loko o kēia wā, ke'ūhū ha awina i loko o ke koko, piʻi pū aie i ka iwi isoenzyme. Ma ka lua o ka hapalua o ka hāpai keiki, a hānau 'Imi hoomahuahua a me ka make ana o ke keiki i ka hua i loko o ka lehulehu o placental isoenzyme.

Mahuahua o ka lehulehu o kona'ākilikai phosphatase i loko o ke koko pinepine ua kakau ia ma ka pathology o ke akepaʻa a me ka iwi. Parenchymal ake poho ke kumu no ka hōʻemi iki mahuahua ma'ūhū haʻawina i loko o ke koko lāʻau lapaʻau, e like me kona'ākilikai phosphatase pili me ka aeea membranes. I ka lapaʻau hepatology ake isoenzyme mea hōʻike no kaʻike, o ka cholestasis. Kēia mea ma muli o ke hoonuiia hoʻololi kemikala o ka bile leki uea keena AP a me'ūhū hoʻokaʻawale 'aʻe i loko o bile. Hyperenzymemia mea oi loa kiʻekiʻe iloko o ka ulu ana o pathologic kaʻina a me ka bile stasis ma ka akepaʻa bile ducts. A laila, ua hoomahuahua ia tenfold ka enzymatic hana o'ākilikai phosphatase i loko o ke koko lāʻau lapaʻau. Inā ka poino intrahepatic biliary'ūhū hanana hulina i loko o ka piʻi pū koko 2-3 wale wa. 'ākilikai phosphatase kūmau no nā mākua mai ka 31 makahiki e i 39,0-92,0 Iu / L ma hope o 31 makahiki - 39,0-117,0 Iu / L. 'ākilikai phosphatase ana i na keiki ma lalo o 10 makahiki - 106,0-213,0 Iu / L i 3 makahiki - 71,0-213,0 Iu / l, a no nā pēpē i - 35,0-106,0 Iu / L.

Ma ka pathology o ka iwi, ka wā ma laila ua mahuahua ha awina o osteoclasts, i ka ulu ana o rickets, osteodistorofii, hyperparathyroidism i loko o ke koko maoli ka ha awina o ka iwi kona'ākilikai phosphatase. Ma keia hihia, no ka huina o kona'ākilikai phosphatase hanana hulina i loko o ke koko, a mahuahua nui ma 3-10 manawa. No ka kakahiakaʻike, o rickets a me osteodystrophy mea he maopopo mahuahua ma ka phosphatase hanana hulina i loko o ka synovial loli. I ka mahuahua ana i loko o kona'ākilikai phosphatase hanana hulina i loko o ka cerebrospinal loli mea he hoailona o ka pio ana o neuronal membranes, kahi e ua IIeEeAIEUIeXAIIUE.