Antibiotic "Linezolid": aʻo no ka hoʻohana 'ana, kuai counterparts, ke kala palapala a me nā hōʻike manaʻo

Ka hapa nui o ka ike lapaau mea koʻohune a mea hoʻomaʻi nā mea palahēhē amenable i ka hana maikaʻiʻole eʻike mau ai '. Eia naʻe, loaʻa nō pathogens mea i hakuloli ai i ka ai-kapaia nosocomial ana. Na kaua e ku e ia mea he mea paakiki hana, no ka mea, he nui loa ai 'ka mea wale e Aʻole e holopono ana. Antibiotic "linezolid" pili ia i mau ai 'me ka i hiki ke hana i laila,-kapaia nosocomial nā mea palahēhē' ole 'ē aʻe hoʻopale i nāʻano o nā ai'. O ia ka leo no ia, a e e kūkākūkā i loko o kēia 'atikala.

hōʻikeʻano

Uluwehi O "Linezolid" kuhikuhi pili i antimicrobial laulā-pae. E like me kona hoʻokumu paʻa waiwai, a ano e pili ana i ka papa oxazolidinone i ka ikaika, a huahelu o ka hana ku e microorganisms ma na mea he nui i ka mahalo i oi i ka lāʻau "Vancomycin" a me nā huahana me ka like haku mele 'ana.

I kēia lā, loaʻa nō kekahi mau 'ano o antimicrobial Agena "linezolid". Product palapala, e ka hapanui pinepine ia i loko o Inc, - i kaʻili lahilahi iwi papa i loaʻa ka 400 a me 600 mg oʻeleu waiwai. Eia hou kekahi, ma ka 'inikua hoʻomaʻamaʻa infusion pāʻoihana ua pinepine ia, i loko o kēlā me kēia mililika me he 2 mg oʻeleu waiwai, a ka pauka (granules), e hoomakaukau i ka wehe, o ka lehulehu o ka hana' Oponopono i mea 100 mg no 5 ml o hope huahana.

nāʻikepili

E like me ka olelo mua i loko o kēia 'atikala, ka lāʻau "Linezolid" manual ia kekahi e hana i ke alo o nā mea palahēhē, kena ae la ia e koʻohune hoʻopale i nā antibiotics. Mau nā nā gram-maikaʻi a me ka gram-io microorganisms pili ana i ka anaerobic a aerobic ano e i ulu ia'ku (kumupaʻa) i ka methicillin, gikopeptidnym i huiʻia, penicillin a me nā antibiotics.

Ka papa inoa o nā maʻi no a he "linezolid" medicament aʻo kikowaena:

• haukapila ole kaiaulu lilo pneumonia;
• ili nā mea palahēhē;
• pahee'aʻaʻa nā mea palahēhē;
• Other nā mea palahēhē kena ae la ia e antibiotic-hoʻopale Enterococcus.

E like me ka rula, ma mua ka hoʻohana 'ana i kēia k lawelawe' ia noiʻi e kuhikuhi i ka ia'ku o pathogens i'ē aʻe ai '. Inā ka mea ua loaʻa, lapaʻau ua lawe mai me ke kōkua o nā antimicrobial ai '.

Contraindications

I ka papa kuhikuhiE a me ka loa nui contraindication i ka hoʻohana 'ana i ka antibiotic' Linezolid 'kauoha no ka hoʻohana pili i ka hypersensitivity ia ia. Ua ua no hoi e waiho i ka hoʻohana i ka lāʻau no ka iapaau ana o nā mea maʻi, ka poe i lawe 'ē aʻe ai' o ka pae mai o Mao nā mea kūpale. Eia hou kekahi, ka mea i paipai no keia Agena pu me tricyclic antidepressants a me ka 'ona hiki hoi e hoala i ke koko, (epinephrine, dopamine, a me nā triptan).

E hoomakaukau ai "linezolid" (na papa, infusion pāʻoihana a me ka slurry) ua contraindicated i ka maʻi e like me hypertension, hyperthyroidism, a seratoninovy carcinoid maʻi pale, feohromotsitoz. Pono e 'akomi i ke ola ana o kēia mau contraindications mua o ka hoʻomaka' ana o ka lapaau ka hoʻohana 'ana i ka lāʻau.

Keʻano papa hana o ka hana o ka ai 'i loko o ke kino

Hana "Linezolid" lāʻau 'ku i kona waiwai, e aeie i ka unuhi kaʻina hana o ke kumuʻiʻo hale a ma na keena o ka koʻohune. Aie i ka ka hoʻonuiʻana o microorganisms ua pani, a he mea i ko lakou make. Ia'ku i ka lāʻau i loko o ka hapanui o ka koʻohune ua lawe loa lohi.

Ma hope o 'ai, inu o ka lāʻauʻeleu' Oponopono ia ke metabolite hydroxyethyl glycine. Ke degere o ka hui me ka wai koko nā polokina hoʻokō 'ia he 31% hula. I keʻena hoʻokolohua haʻawina i loaʻa i ka hui komo i loko o nā mea a pau nā'aʻaʻa a me nā loko. Ua hoi mai ka hiki e hele ma ke keiki i loko o ka fetus a me ka umauma waiu (i kēia waiwai o ka lāʻau i ka lewa i loko o nā koi o ka lawe ana i ka lāʻau ma ka hapai keiki, a lactating wahine).

Ka hapa-ola o kaʻeleu waiwai a me kona metabolite excreted mea 4.5-5 hola. Excretion mea Via ka urinary'ōnaehana (50% like me ka metabolite a me ka 35% kōna), a ma ka digestive'āpana (ole e emi malalo o 9%). Piha excretion ia lŘlŘ loko o 8-12 hola ma hope o ka loaa ana medicament.

Pehea e lawe "Linezolid"

Poe akamai i kuhikuhi mai ia i loko o ka hapanui o na hihia o ka hoʻomanawanui hiki ole kū kaʻawale e ka hoʻoholo ma luna o ka ano o ka? Eaia "Linezolid" lāʻau. Note, na papa, pāʻoihana a me nā emulsions i mea ole manaoia like kaawale hoomakaukau, a me ke ano o ka lāʻau, i loaʻa ma kēia wahi piha lāliʻi. Ma lalo nō o nā kī nui e pili ana i ka laʻau heluna a me ka lōʻihi like 'ole o ka Inc.

Medicine "Linezolid" manual paipai ka hoʻohana 'ana i ka manaʻo i kēia:

1. A pāʻoihana no ka infusion ua lawelawe intravenously 2 manawa i ka lā. A hookahi mahele lāʻau o 400-600 mgʻeleu waiwai. Ka lōʻihi like 'ole o ka lapaau hilinaʻi nui ma luna o ka oolea o ka maʻi, a kona IIeEeAIEUAA ~. Nō kāu, ka hapanui o nā mea palahēhē pono i ke au o ka ma ka liʻiliʻi loa 10, a ole aku ma mua o 14 mau lā, a me wale i ka maʻi, kena ae la ma ka enterococci, lapaʻau mau mai ka 2 a hiki i 4 pule.
2. E hoomakaukau ai "linezolid" (papa) ua ia me 2 manawa i ka lā i loko o ka nui o ka 400 a me 600 mg no? Eaia. No nā mea maʻi elemakule 5 i ka 14 makahiki, i ka laʻau heluna he pōpilikia ma luna o ka muli o ke kino ke kaupaonaʻana, a ua 10 mg no 1 kg o ke kino ke kaupaonaʻana, 2 manawa i ka lā. ʻO kā mākou mahele lāʻau no, inu (p.o.) e ole oi 600 mg. Ka lōʻihi like 'ole o ka Inc ua nānā' ia e ka ia kiko'î i i noʻonoʻo pono ma luna.
3. Granules, na mea i hanaia o ka emulsion, noi e ka luna noaia. laʻau heluna i ka ho omaulia ia ia ka pono, e lawe mai e like me ka ia lula.

Mai ka lāʻau "Linezolid" ua ia wale nō ma ke kuhikuhi a me ka ua ia wale nō i loko o ka haukapila, he overdose o keia hale, a me ka nānā aku o haʻiʻaoʻao waiwai iʻaneʻane eliminated. Kauka i loko o kā lākou mau hōʻike manaʻo i oleloia hihia o ka oi hoʻomāhuahua i loko o ke kino o kaʻeleu lāʻau waiwai a me kona metabolites aie i kāna hana o ka urinary nā loko, a me ka akepaʻa. ka mea, IeAUPIIe, IAa IO loa koke weheʻia nā hopena o na overdoses, e like me ka hoʻomanawanui ua, ua malamaia lakou nei, ma lalo o ka ikaika nā limahana o ka hoʻomalu.

lāʻau hana kūleʻa

Mai kekahi o ka laʻau helunaʻano o ka lāʻau "linezolid" ua manao ia no ka intravenous hooponopono, ia mea pono i ka lāʻau mea pono hana maʻalahi me ke kumu o pāʻoihana hoʻohana i lapaʻau (5% monakō koko pāʻoihana, 0,9% pāʻoihana o ka paʻakai koloriside a me Ringer ka pāʻoihana).

E e uku ai i ke ano o ka hoʻomanawanuiʻana, ka mea ma ka hou ana i "Linezolid" lawe adrenergic ai 'mau noonoo. Inā he piha rejection o ka la mahope mea,ʻaʻole e hiki, lapaau pono e nānā i kā lākou laʻau heluna.

Medicine "Linezolid '(like i loko o ka haku mele' hiki ke equated no hoi ia ia) o loa hana maʻalahi me na ai '" Chlorpromazine "," Cotrimoxazole "" Diazepam "a me" Phenytoin ". Inā ka hoʻomanawanui ma mua o ka noi o ka antibiotic nō ia mai la mea i pono, e hānai iā wā mawaena 3 mau lā ma mua o ka lapaʻau "linezolid" hoʻomākaukau.

Cautions

E like me nā koi ma o ka hoʻohana 'ana o antibiotics "Linezolid" manual he' ike e pili ana i ka wahine hapai keiki, a kanaka me na comorbidities. Eia hou, e kuhikuhi mai la lakou i ka manawa kūpono o kaʻaoʻao loa. Akā, mua na mea mua.

Like no ka hiki aku "Linezolid" lāʻau hōʻike manaʻo o nā kauka e kamailio e pili ana i kūikawā mālama nui ka wā lawelawe i ka hapai keiki, a lactating wahine. O ke kumu ho i ka mea ana i ke kanawai a me ka lāʻau ma ka ulu fetus a ke keiki keiki, ua insufficiently? Anoee. Nui, lapaʻau mea me kona hoʻohana mea pono wale ina ka pilikia a hiki i ka fetus me ka nui loa ma lalo o ka pomaikai kakali ana i hiki i ka makuwahine.

A paakikiʻaʻa puʻuwai a hepatic 'ole, i noi aku akahele noi o ka lāʻau, no ka mea, e excreted metabolitesʻano nui i loko o kēia mau nā loko, a me hoʻomāhuahua ana o kēia mau' ona i loko o ia e i mea hōʻemi o ka hoʻomanawanui.

ʻaoʻao waiwai

Ma muli o ka hopena o ka lapaʻau loina, undesirable reactions o na nā loko likeʻole a me ka nenoai ma ka? Eaia antibiotic "linezolid" loa pinepine lakou aloha ia na ko mākou hopohopo a me ka digestive nenoai. About 10% o nā mea maʻi i lapaʻau i mālama nausea a me headaches. A iki emi nui kou manaʻo e pili ana i kā lākou diarrhea, pōniuniu, a me ka candidiasis ma moʻolelo o ka mucosa.

I hou a hiki i keia, o ka poe akamai i kuhikuhi mai ia hua'ōlelo i makemake 'ole ana i ka lāʻau' likeʻike ākea neuropathy, ke kāʻili 'ana, pilikia makapō haunaele (a kona huina lilo), thrombocytopenia, serotonin maʻi pale, angioedema a me anaphylactic kŰia. Aie i ka mea i ka lāʻau ua hoʻohana 'ia wale nō i loko o ka haukapila' ia, e käpae 'pinepine hoʻoponopono hopena.

Lapaʻauʻikeʻia undesirable reactions ma ka aoao o symptomatic a me ka 'oihana. No kona wehe 'ana i ka lāʻau' mea hiki wale ina ka oolea o kaʻaoʻao 'ole mea he nui pilikia ma mua o ka maʻi, ua malamaia lakou nei, noʻonoʻo antibiotic.

Uluwehi O analogues "Linezolid"

Heluhelu paha i ka ninau e pili ana paha i ka "Linezolid" analogues o ka lāʻau ma laila. O ka holo ana, no ka mea lāʻau lapaʻau market ina i piha, ka mea i he mau ai 'ia e like me keia antimicrobial haku mele' ana. Mau ai 'pili Serb antibiotic "Zeniks" Norewai "zyvox" a me kaʻIseraʻela "Linezolid Teva". I ka haku mele 'ana o nā mea a pau o kēia mau ai' like me ka ka papa kuhikuhiEʻeleu waiwai i komo linezolid.

He loaʻa nuiʻokoʻa ma waena o nā mea a me ka hoomakaukau "Linezolid" i helu 'ia ma luna? Ke kumu kuai o ka ai '- i ka ke kumu unuhi. Ka mea o ia nei ke ao hookahi mele, mau ai 'lawelawe ma ke kanaka kino i like ka ia:' īnea nei me ka ia microorganisms, i ka ia adverse 'ole i ka ia contraindications. Ka mea, oko iki manawa a me ka lapaʻau ki ina hana like, like hoʻi me ka laʻau heluna.

E like me ka rula, o ka oi pipiʻi laweia analogues "Linezolid" antibiotic hoʻohana ma o ka hanana i kēia mau lāʻau mea,ʻaʻole i loaʻa i loko o drugstores. Kēia ka hana pinepine, no ka mea, o kona pono ana i ka laulā huahelu o nā mea maʻi mea kokoke hiki ole no i kuhikuhi ka lapaʻauʻia, a overdo ma luna o nā shelves eʻaʻole e nā mākau 'kekahi o ka hale kūʻai lāʻau lapaʻau kaula. Mai keia uuku aoao nā kau inoa ai ', a, no laila, i ka manawa ma kekahi mau wahi, e kuai lilo aku a pau i heluʻia.

Ke kumu o ka lāʻau

Nā medicaments o ka oxazolidinone pae i ke kiʻekiʻe lilo no i ka luna 'multistep hoʻololi kemikala o ka waiwai i loko o mea lāʻau lapaʻau keʻena hoʻokolohua. He aha ka ke "Linezolid" lāʻau kumukuai? Papa (maʻiʻo o ka papa kuhikuhi hana waiwai 600 mg, pack no 10 moni) ma hale kūʻai lāʻau lapaʻau nā kaula hao e ma ka liʻiliʻi 18 tausani. ʻO kā mākou waiwai o keia laʻau heluna palapala he 20 tausani rubles no 10 na papa. Iki ho'ēmi mea i ka lāʻau ma ka mahele lāʻau o 400 mg. Kona kumukuai mea ma kahi o 17-18 tausani rubles no 10 na papa.

Ke kākoʻo pāʻoihana no ka infusion "Linezolid" oe ke kuai i kona wahi ho'ēmi: pack o ka 10 o nā pākeke 100 ml, e loaʻa 7.5-9 tausani rubles, 10 he huihui 'o ka 300 ml kēlā - i 15,3-16,2 tausani rubles.

Ka hoomakaukau ana o na ia inoa, i mea nui ho'ēmi, pinepine huli mai e ia i ka hoʻopunipuni, a, ma ka maikai, i ole ia ma luna o ka hoʻomanawanui ka kino. Aka hoi, i ka lohi ma Inc no ka maʻi, a kokua pakele o ka antibiotic 'Linezolid' iho ka noho pilikia loa. A no ke aha la poe akamai i waiho aku e kiʻi i ka lapaau wale i loko o keʻena kūʻai lāʻau lapaʻau me ke kaulana maikai.

Comments e pili ana i antibiotic "Linezolid"

Kekahi mau kumu e ponoʻole loaʻa hōʻike manaʻo e pili ana i antibiotic o keia papa. Ua pili pakahi aku la ia i ka ike e pili ana i kona komo, nā mea maʻi i ho'ākāka 'ia. Ke kumu o ua pinepine nā mea maʻi i Inc i ka mea nui ana, a me ka hoomanao i ka oeaa ia-imua o ka manao ana ia mea paʻakikī loa,

Hoʻomalu, ma ka huli, pane i ka lapaʻauʻia "Linezolid"'āina maikaʻi. E like me ia ia lakou, i ka lāʻau mea hiki ke Makuakane me ke ahiahi, i ka loa hoʻopale germs. Ka mea, i kuhikuhi mai i ka pilikia o ka complications aie i kaʻaoʻao waiwai, aole hoi overdose meaʻaneʻane nonexistent. O ke kumu ho i ka mea i ua hoʻohana wale i antibiotic ma ka haukapila napoo ana no hoi. Ma ka hoailona mua o allergic paha adverse reactions i ka lāʻau e haliia mai la mawaho i na mea e pono ai 'inikua hana e hoʻopau ia.

No laila, nānā mākou i nā mea kiko'ī a pau o ka lāʻau "linezolid". Ua hoakakaia Na Ke Kumu no ka pomaikai, a me ka uku e hiki lāʻau reactions ma keia pepa me ka au mamuli. It E e kaulana ia, hoʻowahāwahā i ka kiʻekiʻe lilo o ka lāʻau, ka hoʻohana 'Ua hoaponoia ma na hihia. E hooholo i ka iapaau ana o nā mea maʻi i kēia k hiki wale kauka.