mail bilirubin
Naehana kuleana pili i hoʻolako a pau koko nā'aʻaʻa o ke kino e pono ai ka nui o ka o oxygen lawe e loa hana kūikawā mea hoʻoili - hemoglobin - i loko o ka 'ole o ka ula koko keena. Eia naʻe, i kēia mau keena i ke kaupalena ola kīkoʻo kona, averaging 100-120 lā. Next ka mea, e komo aku ai i ka kroverazrusheniya nā loko, kahi e hookuu hemoglobin. Ua hoopaa ana haptoglobin a koke kaʻi aku i na keena o ka reticuloendothelial'ōnaehana no hou huli ana i ka pili-ʻawahia pigment (pololei bilirubin) a kaʻawale i ka bile. Ma macrophages a histiocytes hemoglobin initially decomposes i ka biliverdin, i mea heʻehā mau apo pyrrole ua hoʻopili methane uwapo. A me ka hou, he mea kona ka ho'ēmiʻana i ka noa bilirubin, a ua lawe pio nā polokina conveyors, a kaʻi aku i ke akepaʻa. I kona parenchyma o kona loli i loko o ala bilirubin, oa ka paa glucuronate no kona hoʻolilo.
Ke kūlana o nā koʻohune
Paʻa mau kūlana ma ka hou reactions ma ka auaaeaiea o bile pigments hanaʻia ka mea maʻamau intestinal microflora. Bilirubin ua hele pololei mai i ke akepaʻa, i loko o ka haku mele 'ana o ka bile i loko o ka vesica fellea, a me ka wā wehe faterova teat komo ka duodenum, a no hoi, ma ka liʻiliʻi naʻau liʻiliʻi, kahi i kuuia mai glucuronicʻakika, a hoohuliia mai i loko o sterkobilinogena outputting na faeces. Part no ka mea, i ka wa a maalo ae la oia ma ka rectum ka paka i loko o ka hemorrhoidal aa koko komo i ke koko, piliwaiwai i ke ake, a me excreted ma nā puʻupaʻa i loko o ka mimi. Penei, i ke koko mau ia akulla like noa, a me ka pololei bilirubin. ka mea hope ana i kahi o 5.1 Mol / l, a me ka huina o - 15.
ʻike, o ke ake mai
E like me ke kuekueni, a me ka lākiō o kēia nā hoailona hiki e hookolokoloiaʻi e au, ma ka functioning o ke akepaʻa. No laila, inā i ka parenchyma o ke kino i ka infectious pahaʻawahia poino, ka hapanui o ka noa pigment, a koe MAKAHIKI MDCCCXVI NU, a me ka lehulehu i loko o ke koko o nā ano o ka pigment, piʻi pū dramatically. Direct bilirubin i loko o ke koko ua 'akomi i loko o ka no laila, i kapaʻia obstructive jaundice, ma a ma laila nō nā pilikia i ka maʻamau pele o ka bile, a no ia mea, bile regurgitation ia lŘlŘ i loko o ke koko. Ke kumu no keia hiki e mīkini'opihia bile leki uea hikoko o ka pancreas poo, pohaku, etc. obliteration. Ma suprarenal a me ka jaundice, i ke kumu o ka a ua hoʻokāʻoi 'ka palaho o hemoglobin i loko o ke koko. Kēia e loli hemolytic toxins a me microbial toxins, kekahi o ka physiological kulana. Eia naʻe, a me kēia mau 'ano a pau o ka hepatitis bilirubin kükulu i loko o nā nā'aʻaʻa. MAKAHIKI MDCCCXVI NU pela no ka mea, o kona lipophilicity, ia eaaei komo i loko o aeee, a me ma ke koko-lolo ke'ākeʻakeʻa mai, a hoʻokaʻawale i ka huina'ine amo kaulahao ma ka mitochondria, hiki inhibiting ikehu pūnao. I pakele i loko o keia manao, pololei bilirubin, nona ka kūmau mea ole-ʻawahia, no ka mea, mea insoluble lātoma.