Bisphosphonates - He aha ka mea? Bisphosphonates no ka osteoporosis

Musculoskeletal'ōnaehana hanaʻia kekahi o na kumu nui mana i loko o ke kanaka kino. I ka mea, o ke kākoʻo no a pau na kino. Iwi ola Radio kūlana ano nui i. Ka manawa, aia no na pilikia i loko o na ami, spine, pinepine fractures ana, i ke kanaka o ka pono o ke ola ua me ka nui loa hoemiia. One ia maʻi a ua pinepine pu ma na symptoms mea osteoporosis.

Inā ma ka manawa, e ike i ke kauka, ka mea i hiki ia me ka nui loa hoʻoikaika 'o ka hoʻomanawanui i ka ke ano. Currently, bisphosphonates hoʻohana i ka pono osteoporosis. Mau ai 'ke haawi aku ka manaolana o ka daimonio. E ka ike i ke ano o ka ai '.

He aha nā bisphosphonates

Kona inoa, i kēia pae o ka ai 'ua loaa mai no ka mea, o ka maʻiʻo ma ke' ole o nā phosphonates. Keʻano papa hana o ka 'ana ua mana no ka mea, o ka mea nunui mea like me ka pirofosfonatami ana i ka nui hopena ma luna o ka rula o ke kalipuna maʻiʻo i loko o nā iwi.

Me ka like 'ole, bisphosphonates inhibit nā'ūhū i hiki ke hoolilo o ka pirofosfonaty. Ka mea, he e nakinaki kalipuna Ion, a kaʻi aku iā lākou hoʻi i ka iwi.

I ka maikaʻiʻaoʻao o ka? Eaia o kēia mau ai 'o ia i ka ai' i pihaʻi me bisphosphonates, i wale kekahi e wae ia ma luna o ka skeletal'ōnaehana, ma ka hoʻomāhuahua o ke kalipuna.

No ka mea, o keia hana ma ka iapaau ana o ka osteoporosis ia mea hiki ke pale aku i ka hookaheia'na o ke kalipuna a me phosphorus, a mea he maikaʻi ia ma luna o ka iapaau ana.

ʻano likeʻole o nā bisphosphonates

He nui nō mai i ike e pili ana i bisphosphonates. He aha ka mea? Ua ua manawa ulu ke kolu o ka hanauna o keia pae o ka ai '. Kauka e hoʻomau i ka hoʻohana 'ana ai', a me na hanauna mua elua. Ano, he nui loa ai 'inherently pihaʻi bisphosphonates, a pau no ia hiki ke maheleia i mau nui pūʻulu:

1. Simpleʻaʻole i loaʻa ka naikokene.
2. Ka hui ana o bisphosphonates, i nā naikokene - aminobisphosphonates.
   

I ka likeʻole ma waena o nā pūʻulu elua moe i loko o ka mea i ka mea, i kekahi mau 'ole ma luna o osteoclasts.

Naikokene-i loaʻa bisphosphonates

He aha ka mea? Mau dala i loko o kona haku mele 'ana iloko ona i kakauia na kēia nā mea hoʻohui:

1. Ibandronatovayaʻakika e pili ana i ke kolu o ka hanauna, synthesized nei ua hoʻohana loa ana no ka Kāohiʻana o ka osteoporosis i loko o nā wāhine, maopopo menopausal.
2. Zolendronovayaʻakika selectively hana ma luna o ka iwi'aʻaʻa, i ka hai Anati-ʻeho kanawai. Ma ke kumu o keia waiwai i lawe ai 'e like me "Zometa", "Zolendronat".
3. Alendronate paʻakai correctors pili i 'ole-hormonal pūnao ma ka iwi'aʻaʻa, paipai' ia ka pono ho okumu o ka iwi 'ole.
4. Ibandronate paʻakai ma luna i paka "Bonviva", "Boniva", "Bondronat" inhibits osteoclast haʻawina, akā, 'aʻole e pili i ko lakou helu. Mau bisphosphonates no ka hana maikaʻiʻole o ka osteoporosis i ka hoʻokō, o ka oi aku me he prophylactic Agena ma menopausal wahine.
   

E makaala i oe e ole pakiko-lapaʻau, pono e hoakaka ia ka lapaʻauʻia e ke kauka.

na mea bisphosphonates

'Aʻole i loaʻa ka naikokene bisphosphonate ai' no ka osteoporosis mea i 'Imi i hoʻohana. Mau nā:

1. "Etidronate" i loko o ka palapala o ka papa, a injections. ka mea, ua pinepine hoakaka ole wale osteoporosis, akā, no hoi no ka Paget ka maʻi, hypercalcemia, a ia lŘlŘ ma ke kāʻei kua o ka maʻi 'aʻai.
2. "Clodronate" ua hoopuka ia i loko o ka palapala o capsules, papa a me nā pāʻoihana. Haʻi'ōlelo osteoporosis a me ka osteolysis.
3. "Tiludronate" ana i koi 'ia wale no nā mākua i hana eha iaʻi mai Paget ka maʻi. Keiki, ka mea, ua contraindicated.
   

Ua Ua manaoio ia mau pūʻulu mau o ka ai 'i okoa' ole ma ke kāne a me ka wahine kino, no laila, nani wāhine mea maikaʻi hoʻomākaukau naikokene-i loaʻa lāʻau. Ma kekahi hihia, i ka poʻe uʻi a mea e hana wale nō kou kauka.

Hopenaʻoi loa i ka maʻi likeʻole

Aia ka he okoa papa inoa o ka maʻi no i bisphosphonate Inc hiki i ka maikaʻi ia.

1. Osteoporosis.
2. Myeloma.
3. Ino osteodystrophy.
4. Helu hyperparathyroidism.
5. 'Aʻe' ana o ke kaʻina hana o ka iwi ho okumu.
6. I ka iwi metastases.

Kēlā me kēia no kēia kūlana wale nō ke kauka prescribes he lāʻau, kona laʻau heluna a me ka lōʻihi like 'ole o ke ana. Komo ma ka pakiko-lapaʻau, ke hoeha wale i ke kino.

ʻano papa hana o ka hana

Mai bisphosphonates no ka osteoporosis ai 'i ka loa hoʻomano hoʻohana', e mea pono e elucidate i keʻano papa hana o kā lākou hana.

A pau na keena o ko makou kino, ua hōʻano hou 'ia ma ke kamepiula, ka ia hiki ke olelo mai no o ka iwi. Ua Ua mālama 'ia e ke koena o ka osteoblasts, i mea kuleana no ka hoʻololi kemikala o hou'aʻaʻa, a me osteoclasts i kuleana no kona luku. No laila, BF somehow kupaianaha iaʻi alalai mai i ka hana ana o osteoclasts, a ma kekahi mau hihia i kāheaʻano papa hana o ka hoʻoponopono-luku.

Ua ua olelo mai ia i ka mea keia manawa,ʻepekema i ua hikiʻole i ka maopopo pohihihi mai pehea e kahu ai bisphosphonates aeie iwi luku. Ua ua waleʻike i i e hui mau ai 'me hydroxyapatite i loko o ka iwi'āpana, hiki hoʻololi i ka iwi anuenue.

E hiki no hoi e hoailona oukou ia ina ia no ka lōʻihi manawa, i no ka maʻi 'aʻai Inc ma muli o kēia mau kŘpa a nā bisphosphonates hoʻohana i ka pono osteoporosis.

Bisphosphonates metastases

Me ka hooulu ana o ka maʻi 'aʻai hele mai ana i ke kahua o Ka maʻi' aʻai aeee i mahuka mai ka iniiaiieʻeho a me kona laha mawaena o ke kino. Ma ka hou wahi a lakou i pili, a hoʻomaka i ka ulu, ho okumu i metastases.

Ka iwi'aʻaʻa ua mau i ka moʻolelo, pela ka mea maoli i ka likelihood o ka maʻiʻaʻai ma hematogenous. Ka maʻi 'aʻai keena komo ka wā i loko o ka iwi ka lolo, ka mea ma loko o ka maʻamau interplay ma waena o osteoclasts a me osteoblasts, a hiki aku i ka'āno'ē kūpono' ana o ka iwi a'aʻaʻa.

Mai kau i ka alo o ka metastasis ka pilikia, no ka mea, i loko o ke kakahiaka nui kahua o ka hoʻonaʻauao, i kēia kaʻina ia lŘlŘ kokoke me ka symptoms, me ka maʻi 'aʻai pono kekahi, i ka hoʻokolokolo pono keia hookolokolo ana, e hōʻike haumāna foci.

I waena o nā kūlana kanaka metastases e hoʻomano i hoʻohana Bisphosphonates. Mau ai 'i loa hoopuni tolerated e hoʻomanawanui iki mai, ka mea kākaʻikahi iʻaoʻao ole.

Ka mea, hiki ke hui me ka radiotherapy a me ka chemotherapy. I ka hoʻohana 'ana i na ai' i hōʻike 'ka ho'ēmiʻana i loko o ka mea hiki wale mai o ka iwi metastasis ma ka umauma Ka maʻi' aʻai, a me ka mau myeloma.

Ka wā e hoʻomōhala ana i hypercalcemia i mea kokoke maʻamau ma oncological maʻi, ai 'i ka hookoia nui i loko o ka palapala o ka injections a me infusions. Maikaʻi loa i nā hualoaʻa i hōʻike na 'ano like "Zolendronovayaʻakika", "Pamidronate". lā kela manawa, he mau hope he lālā o ka lapaʻau ho'āʻo ma hōʻike normalizing koko kalipuna, a me ka hope ke hoomau ana no i ke mau lā.

I Kekahi Mau koi no ka loaa ana bisphosphonates

Inā 'oe i ole lohe no bisphosphonates, mea ia mea, e hai aku i ke kauka. Ae o kēia mau ai 'e halihaliia oia iwaho e like me kekahi mau rula:

• Oe e lawe ka lapaʻauʻia ma hope o hoala mai la, ma ka liʻiliʻi loa hoʻokahi hola ma mua o ka meaʻai.
• Holoi ia me ka nui o ka wai e e.
• Mai hoʻohana zapivaniya'ē aʻe ke kinowai, e like me ka wai, kī, ke kope. Ka mea, pale aku i ke omo o bisphosphonates.
• Ma hope iho o ka hoʻohana 'ana i nā papa hiki ole moe iho, e hookiekie ae e pili ana i ka hapalua o ka hora ma ka pololei kulana, e pono ai i ka esophagus ua ka palena haʻahaʻa.
• Ua UaʻAʻole pono e hui pu iho i ka? Eaia BF me ka kalipuna supplementation, makanekiuma, he hao a me ka Aluminum.

Inā e hahai mai a pau o kēia mau koi, i ka bisphosphonate e lawe mai hua'ōlelo i makemakeʻaoʻao ole.

Bisphosphonates no osteoporosis: pros a me ka hooluolu

Ma ka iapaau ana o mau hoʻohana bisphosphonates no osteoporosis. Na ai 'i hoʻohana like pono no na kane a me na wahine. Ke kumu pono o kēia mau ai 'e pololei:

• Ua 'Aʻole i loaʻa hormones.
• Mai Mai hoʻonui i ke kūpono 'ana o ka mea'ōnaehana mānowai koko ka maʻi.
• Malignant hikoko hoʻohana BF i holo.

Akā, i loko o kekahi mea poni i ka manawa e hiki ke loaʻa i ka nalo, i loko o ka mea poni. Bisphosphonates, hoʻowahāwahā lākou hopenaʻoi loa i loko o ka iapaau ana o ka osteoporosis, mea no mamao mai ka hemolele. Excessive entrainment o? Eaia ke haawi aku i ka i kēiaʻaoʻao ole:

• He kūlana maikaʻiʻole i ke akepaʻa a me nā puʻupaʻa.
• Inā lawelawe intravenously, e hoʻoneʻe 'ia paha e hoʻomōhala hypocalcaemia.
• Ua hiki e ka esophagus paha'ōpū ulcer.
• Aia mau rashes ma luna o ke kino.
• Ma kekahi aia mea he mau nawaliwali, malaise, a me ka nausea.
• Pain i loko o nā nāʻiʻo.
• Hihio pilikia.
• Diarrhea a diarrhea.
  

Mākou hiki ole ke olelo ia a pau o kēia mau undesirable 'ole pono hoike mai ai ia ia iho i loko o nā hoomanawanui, akā, e pono e ike e pili ana ia lakou. Inā 'oe i hoakakaia bisphosphonates, mea ia mea, wehewehe i ke kauka,ʻo ia, e koho i ka ia lāʻau laʻau heluna a me ka lōʻihi o ka nohoʻana.

Oia ai 'i mana ma ka lapaau ana o osteoporosis a me nā maʻi. Mua oe hāʻawi i ka lapaau, ke kauka ua koi 'ia e lawe mai i kekahi anamanaʻo e loaʻa mai i ka moku'āina o pūnao ma ka iwi a me ka kalipuna homeostasis, no laila, mai manaʻoʻoe iāʻoe iho, e koi' ia ai 'o keia pae.

, Oe Pono e alakai i ke ola i ke Aloha Hawaii, ma hope a pau koi o ka poe kumu, e ai pono e hōʻalo ai i ka ua i akoakoa ai i ka lapaʻauʻia. Wale i keia hihia, kou skeletal'ōnaehana e e maikai.