Monoclonal nā mea'aʻaʻa. He aha ka mea a ka mea ka mea, no?

Nā mea'aʻaʻa (immunoglobulins) nā polokina kapa Y-shape. Lakou komo 'ana i loko o ka' ike a me ka excretion o na eiiiiiaiou (antigens). Lāʻau lapaʻau kino lawe mai ma ka'ōnaehana paleʻea'ōnaehana ma muli o ke antigen anal. Kēlā me kēia immunoglobulin hiki ke hoʻomaopopo, a kamaʻilio me ka malihini kekahi hehee ai.

Aie i ka mea i na nā mea'aʻaʻa kūhōhō ma ke koko, ka mea e loaʻa ana i kela apana keia apana o ke kino. Ka paa ana o ka immunoglobulin i ka antigen e pale i ka ulu ana o keʻano o ka hanaʻana i he hoʻonui ai i ka maʻi, a alakai ai i ka make ana o ka haole hehee ai.

Ka'ōnaehana paleʻea pane o ke kino a hiki i kekahi, a hiki i ka loa noonoo ole, i kapaia ka ke keʻena haole ua polyclonal. Ma nā hua'ōlelo, ka'ōnaehana paleʻea nenoaia produces (paha ke) he iiiaanoaa o immunoglobulins, e hana me ka okoa antigens.

Monoclonal nā mea'aʻaʻa i-aeea clones. No kela a me keia mea ke kelepona hele ka pale kaua (pale umauma hoʻokahi) ua i ho'ākāka 'antigen no ka ka loaʻaʻana a me ka paa ana o ka'ōnaehana paleʻea'ōnaehana i i, ua ulu ka kekahi immunoglobulin, a ke kelepona hele, hoʻokomo.

Ke Inc hoʻohana synthesized i loko o ke Keʻena, ma mua i loko o ka'ōnaehana paleʻea'ōnaehana, monoclonal nā mea'aʻaʻa. I ka kino, kā lākou kaʻina kānāwai ho'ā hope o nā eiiiiiaiou o ka hoomalu'ōnaehana e luku kekahi antigens. Ke'ōlelo mai, no ka laʻana, wahahee i loko o ka meaola monoclonal lāʻau lapaʻau kino no ka iapaau ana o ka maʻi 'aʻai.

Ka mua clone aeee i i ua synthesized ma keʻena hoʻokolohua, oia loa o ka iole nā polokina. Kēia i hoʻonāukiuki aku i ka pilikia, aole i nui. Ka nui, e hoike ana i ka "iole" monoclonal nā mea'aʻaʻa ke kanaka'ōnaehana paleʻea'ōnaehana perceives like antigens - haole hehee wale, a pela paha ke i naoh ku e ia lakou. Kēia UaʻAʻole pono ke ano o ka ulu ana o ka'ōnaehana paleʻea pane. Pale'ōnaehana i loko o ke kino hoʻomaka e luku aku monoclonal nā mea'aʻaʻa mua ka mea, ke hoʻopōmaikaʻi aku iā ia.

I manawa hala, kekahi o na nā polokina ma ka iole keena hoomaka e auou caiaiai ia e kanaka kumuʻiʻo eiiiiiaiou, i kapaia "chimeric". Me ka mea ulu ma ka like ana o na kumu o kanaka immunoglobulins i (synthesized) i kapaia "humanized monoclonal lāʻau lapaʻau kino".

Hoomakaukau i loaʻa kēia mau eiiiiiaiou, i kapa i na mea o ka hoʻomāka therapies. Ma nā hua'ōlelo, e hoʻololi i ai 'e hana pololei ma na keena, e hoʻonāukiuki i ka hooulu ana o pathological keʻano o ka hanaʻana. He pinepine oi efficient hana ma mua oʻike mau pākōlea regimens. Eia kekahi, he nui wale o na mau laau i manao e hana, no ka laʻana, mau sclerosis, Ka maʻi 'aʻai, rheumatoid arthritis a me nā pathologies eʻawahia, a i kapu ma huina dosages, oluolu no ka hooko ana i ka hoʻomanawanui.

Mawaena o ka loa hanohano lapaau monoclonal nā mea'aʻaʻa e e kaulana na mea paahana, e like me "MabThera", "Rituxan" (hoʻohana 'ia i loko o ka politika-Hodgkin ka lymphoma), ' Herceptin '(hoʻohana no ka umauma Ka maʻi' aʻai).

Ma lapaau he kiʻekiʻe manaolana o synthesizing 'enehana o monoclonal nā mea'aʻaʻa. Eia naʻe, loaʻa nō kekahi mau hoʻokau '. Penei, synthesized immunoglobulins, ua ikaika nui nā lātoma. Ua Aʻole 'ae' ia e komo iloko hohonu i loko o nā'aʻaʻa paha i loko o ke keena. Lakou mea i manao ia no ka moʻolelo (ku una ha) hooponopono. A, e kū ai i ka makemake hopena o ka lehulehu o kēia nā mea'aʻaʻa e ole oi aku mamua o elima i ka umi tausani o na i ka lehulehu o ka pale umauma hoʻokahi antigen. ? Ac? Aaioea synthesized immunoglobulins hula wale nō i loko o aeea hana 'ike loea, a ma ka huliʻo kā lākou? Iecaianoaaiiuo he pipiʻi.