Bullous pemphigoid: symptoms, lapaʻau, a me nā kiʻi

Bullous pemphigoid - he kŘpa a na ili maʻi e kohu ai ka mawaho hoikeana o pemphigus. Ka maʻi ia lŘlŘ i ka maʻi palapala, a ma ka wa e kaawale aku o ke akeʻike, a me ka hana ke alakai i kaʻawaʻawa loa hopena. No laila, i ke kumu o ka ulu ana o keia maʻi? He aha e na symptoms ka mea, hoike mai ai ia ia? He aha ka mea i loaʻa i ka iapaau ana o kēia lapaau, e kaumaha aku ai? Pane i kēia mau nīnau mea o ka hoihoi ana i na mea he nui heluhelu.

He aha mea he maʻi?

Bullous pemphigoid i ke kālā no lapaau ua ikeia ma na inoa - e une lōhai ka maʻi, a me ka senile pemphigus, dermatitis herpetiformis a me senile. He He maʻi autoimmune maʻi, i ua pu ma ke ano o ka ili poʻe noʻonoʻoʻole o ka blister nui (mawaho symptoms i kekahi manawa e hoohalike ai oiaio pemphigus).

Ua mea waiwai 'ana i kumumanaʻo i ka poi pu hapanui o nā mea maʻi i kēiaʻike, - ka mea, o kanaka elemakule 65 makahiki a' oi. Maoli ai, lāʻau lapaʻau ike 'ia, e like me ka maʻi ka i kekahi manawa i loaʻa i loko o nā keiki a me nā waena-elemakule nā mea maʻi. I ka maʻi ua wehewehe aku ma ka benign papa, akā, e hiki i kekahi manawa, e alakai i ka complications. Ka lapaʻau kiʻi o ka pili pomaikai koho 'ē aʻe me ka manawa o ka exacerbation. O ka papa, no ka nui kanaka, i ka ninau o ka uku o ka mea i mea he bullous pemphigoid. Symptoms a me ka lapaau ana i ka maʻi, kona kumu - i kēia 'ike E heluhelu hou ke akahele.

Kekahi like maʻi

Ua mea waiwai 'ana i kumumanaʻo i ka bullous pemphigoid ka hapa o ka pae o ka ai-kapaia cystic dermatosis. Mau maʻi i ike okoa mai ka pemphigus oiaio, no ka mea, ua i pu ma acantholysis. ili lesions pūʻulu kikowaena mau maʻi, i ka lapaʻau kiʻi i ka he like:

• Benign pemphigus neakantoliticheskaya ma a maʻi e loli ai wale nō ka moʻolelo mucosa ole ma o na la rashes ma nā hoʻopunipuni. I ka maʻi ua i wehewehe aku e kekahi benign papa. Ma ke alanui, ka mea i ho'ākāka 'ia ma mua i loko o 1959.
• Scarring pemphigoid - loa he mea pepehi maʻi ia e loli ai i ka mucousʻili lahilahi o ka maka, a me ka conjunctiva, ma o na la ia e atrophy. Rashes ma ke kino e hiki, akā, i hoʻomaka ai kŘpa a infrequently. I ka papa kuhikuhiE kamepiula pūʻulu - nā wāhine 50 makahiki o ka makahiki, eia nae i kekahi manawa i ka maʻi ua palapala iwaena o kāne nā mea maʻi.

Nā kumu a me pathogenesis o bullous pemphigoid

Eia naʻe, ua no i maopopo maopopo keʻano papa hana o ka hanana o kēia maʻi. Eia naʻe, ua hiki ke aho i ka maʻi mea autoimmune ma ka anoʻepekema. No kekahi kumu a me kekahi, aia no na hoʻolako 'ole i loko o ka hana o ka'ōnaehana paleʻea'ōnaehana, kūpono ana i ka hua mai nā mea'aʻaʻa e hoomaau ole wale haole, akā, i ke kino o ka iho keena.

i loaʻa maopopo o keia kumumanaʻo. I loko o ka lāʻau lapaʻau o ka hoʻomanawanui noiʻi, e like me ia ma ka wai a lawe mai i nā Oe, ho'ākāka 'ia i nā mea'aʻaʻa i ua ike e hanaʻino i ka basalʻili lahilahi o ka ili nā'aʻaʻa a me mucous membranes. No hoi, ka mea i loaʻa i ka oi hana o ka maʻi e hoʻomōhala ana i, ka mea kiekie ka titer o kēia nā mea'aʻaʻa.

Ua Ua manaoio aku i ka mea, ua kena ae la autoimmune ka maʻi ma aaiaoe?. Naʻe 'oe makemake i ka ololi e hiki haʻalele i ka maʻi. Kēia hiki e:

• Vaccination ku e kekahi mau maʻi;
• poho ole loa ili ae hookaawale;
• waiū i ultraviolet pāhawewe (lōʻihi sunbathing, solarium hainā, a pela aku ...);
• Thermal'ā no kaʻili;
• pinepine ana o kekahi mau lapaʻauʻia, e like me "Furosemide", "captopril", "phenacetin", "amoxicillin" a me kekahi'ē aʻe;
• I kekahi manawa, i ka maʻi ua ho'ā 'ia paha ma hope o ka hooholo ana o ka hoʻomanawanui pāhawewe Inc;
• ʻaʻa puʻuwai transplant rejection, hui, transplantation hai.

Bullous pemphigoid: Hawaii photo a me symptoms

O ka papa, mua o nā mea a pau ia mea nui, e familiarize oe iho me na symptoms, no ka mea, o ka koke ia ke hoʻomanawanui, e hoʻolohe i ke ola ana o ka 'aʻe' ana, a imi 'inikua'ōlelo aʻo, i ka hiki pono o ka iapaau ana kaʻina lawe wahi. Hoʻonaʻauao ma luna o kaʻili, pili vesicular pele - na kumu nui hiʻona o i ka pu ma ka bullous pemphigoid (Photo hōʻike i ka nana aku o ka poʻe noʻonoʻoʻole). Loa pinepine e loli ai i ka ili o na lala a me ka kumu. Poʻe noʻonoʻoʻole i ke ana i loko o ke kula o ka nui maoli creases ma luna o ka maka, a me ka poo, akā, i ka hana i kākaʻikahi.

I ka papa kuhikuhiE oihana mua o ka pele - vesicles a blisters me ka hoka ai papale hainaka. I loko o loaʻa ia lakou i ka wai, IeAUPIIe, IAa IO aniani moakaka, akā, i kekahi manawa oe e hai i ke koko. Pinepine, i ka ili a puni o ka ula Oe.

Ka manawa o ke "ola" a me ka ho okumu ana o kekahi mau lā. Ma hope iho o ia, ka mea, spontaneously wehe. Ma ka paena o lesions i hana ka'aʻaiawā mau mea a me ka uuku ulcers. Pńpa ma luna o kaʻilikai iʻaʻole i hanaʻia e like me erosive wahi koke epiteliziruyutsya.

Nā kahua o ka hoʻonaʻauao mua o ka maʻi i loko o 20% o nā mea maʻi hoʻomaka me keʻano o nā Oe ma ku una ha i ka mucosa, a laila, komo i ka ili poʻe noʻonoʻoʻole. Blisters ma ka mucous membranes o ka ihu, puʻu, wahine, maka hou loa kākaʻikahi.

E hoomanawanui i ohumu o ka ohane, a ma hope o wehe i nā Oe a me kekahi soreness. Paha i ka mea ulu ma ka wela, oiai keia mea pohihihi. I ka poʻeʻelemākule nā mea maʻi, i ke kino e ua depleted ma pinepine relapses, ua pū akula nō hoʻi i ka emi ma ka ikaika loa ka makemake, paona poho, e holumua ai nawaliwali.

Histogenesis, histopathology a me ka patomorfologija

Pathology bullous pemphigoid mea he hana hoihoi. First cytoplasmic keʻano o ka hanaʻana ma waena o basal keena hana lehulehu vacuoles. Ua mau ka ho okumu ana i merged pu e lilo nui nā hale. A me keia, aia no he hoopaapaa, a edema o na dermis nā'aʻaʻa.

Turo bladder - ka epidermal'aʻaʻa. Aeee kona hohola, akā, na na alahaka ma waena o ia ua i wela. E like me ka maʻi o ka gradual a maloo aku o ka epidermal keena. I ka Ia manawa, hou epidermal'aʻaʻa e kokoke ana me Oe lua penei, paʻa kona lalo - pela vesicles Pńk'pika, maloko o na epidermis a me kekahi manawa ma ka podrogovoy, ahu iho.

Loko o ka Oe aia mea he loli i kekahi mau lymphocytes me ka admixture o neutrophils. Aia nā kaula makalii o fibrin, ke kumuʻiʻo nā lātoma a me kekahi'ē aʻe i huiʻia.

Inā ka histogenesis o bullous pemphigoid mākou noonoo, mua ia mea kumukuai e hoomanao ana i ka maʻi mea autoimmune. Ma ka hoʻopaʻa 'ana o nā'aʻaʻa ma ka huina'ine microscope hiki ke kaulana ia pela-kapaia antigens BPAg1, a i hookuu ia ia iloko o ka'ōnaehana paleʻea pane e aia i loko o ka basal, ahu iho, oia hoi ma ka hoʻopunipuni poludesmosom keratinocytes. Kekahi antigen - BPAg2 - kekahi aia i loko o ka wahi poludesmosom. Ua Ua manaoio aku i ka mea, ua hanaʻia ma ka collagen type XII.

No hoi i ka noiʻi ka mea, ua loaʻa i macrophages a me eosinophils ma keia maʻi initially loaa i loko o ka basalʻili lahilahi, a laila, neʻe i ma ia, a hoʻomaka i loaa i loko o ka bladder, a ma waena o ka basal keena. No hoi, aia no he nui degranulation o ke kia keena.

Histologically, ka maʻi ua malama ka wā exfoliation o na epidermis mai na dermis, a ma waena o i ua hana subepidermal blister. i hoomaka na moku ma ka ili nā'aʻaʻa, malaila e haanou ana o ka pā papa (endothelium).

Hoikehonua, ano o kaʻike,

E like me ka rula, ma laila nō i hihia me kaʻike, o na maʻi like bullous pemphigoid: na symptoms i loa kekahi, a no ia mea, i kou kauka i ka manawa maʻamau nana hāʻupu aʻe i ka maʻi mamua. Ma ka hoʻomanawanui i ka ili pilipaa Oe i hana, a me ke kaʻina hana o ka epithelialization o erosions ia lŘlŘ hikiwawe loa.

Ihi ho'āʻo io epidermis. Eia hou, i ka pa ua lawe mai o ka na Contents o na Oe me ka hou histological ninaninau. Ma keʻena hoʻokolohua ho'āʻo ma ke ke loaʻa i loko o ka kinowai vacuoles histiocytic hehee wale, eosinophils a me lymphocytes.

Ma ka kekahi lima, i ka palena pauʻike, i kekahi manawa fraught me ka pilikia, e like me ka lapaʻau kiʻi mea iki reminiscent o nā ili mai, a me multiforme exudative erythema, oiaio a me ka pemphigus herpetiformis dermatitis Duhring.

He aha lapaʻau ua manaoia e e hoʻokō?

He aha ina e loaʻa bullous pemphigoid? Lapaʻau ma keia hihia pono i ka luna '. A, i ke koho ana o? Aaoeiiiiai hana a me ka lapaʻauʻia hilinaʻi nui ma luna o na mea he nui aʻe, a me ka oolea o ka maʻi, i ka makahiki a me ka nui ola o ka hoomanawanui, imua o comorbidities. Ma kekahi hihia, i ka iapaau ana regimen i ke i wale ma ka hele kauka.

Ke kumu o ka Inc - steroid Anati-hoʻoʻino ai 'i loaʻa steroid. Loa pinepine hoʻohana 'ia no kēia mea "Prednisolone". Ka lāʻau 'Ua lawelawe intravenously a me ka laʻau heluna ua ke kiʻekiʻe o ua hoʻemi like me ka nalowaleʻana o nā symptoms.

Nō hoʻi, he kanawai maikai, o hāʻawi cytostatics a me immunosuppressive konohiki e kōkua e normalize i ka functioning o ka'ōnaehana paleʻea nenoaiu. Muli o kona kulana pinepine, e hoomanawanui i hoakaka ai 'e like me "Cyclosporin A", "Cyclophosphamide", "Azathioprine".

O ka holo ana, no ka nui wahi o ka iapaau ana o lesions, erosions a me ulcers ma luna o kaʻili. He pono e malama i ka ili maemae. E hoomanawanui i lawelawe pāʻoihana me ka aniline make (e laʻa me, "Furkotsin") a hana e like antiseptics a maloʻo ana mai i ka ili. I hou loa na kekahi e noi mai ana me ka hinu me steroid.

Iapaau ana me ka poʻe laau

Bullous pemphigoid, a une lōhai maʻi - he pathology e pono i ke akamai, palapala hōʻoia no lapaau. I ka hoʻohana ana i kekahi mau laau lapaau homemade hiki, akā, me ka ae ana o ke akamai wale. Mua 'oe ke hoʻohana i kekahi paha oe e kukakuka pu me kou kauka. I hoolaʻi lapaau hoʻohana i keʻano o ka okoa ai '.

• Ua Ua manaoio aku i ka maikaʻi ana o ke ola kino o ka hoʻomanawanui loli i ka tincture o Eleutherococcus. E ka mea e e palua ka lā, 30 kulu.
• No ka foxmike ana poʻe noʻonoʻoʻole aaioee wai, mai ka lau o ka Aloe, a kokua i ka höʻike aku maneo a me ka soreness, ua ālai 'ka hooulu ana o ka li nui, hōʻeleu e noho. Ka wai e pono ai, e hui i ka lole wili, alaila, pili ia i ka loli ana o ili wahi a koho lole wili. No ka i kā mākou hookoia, e hiki ke uhi wahī me ka ea wahī.
• Me ka wahi mea, he hou wai a me ka decoction o paʻapū lau hiki ke hoʻohana. Poultice i o ka luna-i ho'ākāka 'ia noaia.
• Bullous pemphigoid, a oi kaʻoi loa, kona symptoms hiki ke alleviated me ka hana lāʻau lapaʻau decoction. E hana ia lawe i like dala (50 g) o ka eucalyptus lau, rhizomes'ōwili hao hua Sophora japonica, birch nā'ōpuʻu, yarrow, Kahu hipa o ka aa kala ole, a paʻapū. Elua tablespoons o ka hoomakaukau ukuhiia i loko o ke ahiahi lāʻau ikiʻai, ninini iho i ke aniani o nā kapuahi e ka wai a me ka haʻalele i ka pō. Ma ke kakahiaka o ka infusion mea pono e omo a me ka mahele i ekolu apana - lawe ia i ka lā.

Ma ka hoʻomaopopo aku i ka lāʻau lapaʻau lapaau no kēlā me kēia hoomanawanui i hana okoa. Ina o ka Agena i ka maikaʻi hookoia, ma kekahi hihia, mai haawi aku i 'inikua lapaʻau.

Ke prognosis no nā mea maʻi

Pemphigoid - he benign maʻi o ka ili, a no ia mea, lawe wahi i loko o ka hapanui hihia mea i hikiʻole. No hoi, kokoke i kekahi nui kulanakauhale haukapila i hana i ka holomua lapaau no ka maʻi mea no laila, huikau inoa - bullous pemphigoid. Ma Orenburg, Moscow, a me kekahi 'ē aʻe kulanakauhale, oe ua ike hoi, e huli i ka hoʻomalu maikaʻi. Place o ka noho, e hilinaʻi ma ke ole o ka lilo o ka lapaau, mai na kala o kekahi laau lapaau i loko o kekahi hale kūʻai lāʻau lapaʻau 'ikamu ĸokoĸa ana nä pane.

Ka wā pono 'ana i mālama iapaau ana ke kū i ka hale lio kala. Mai manawa i ka manawa ma laila nō kekahi e hoomanawanui i relapse, a, o ka papa, kaʻawaʻawa loa, akā,ʻaʻole ona. Ma ka kekahi lima, ka wāʻaʻole hoʻi he iapaau ana wahi o ka ho okumu ana o lesions i lilo i ka'īpuka no ka maʻiʻaʻai, niioaaonoaaiii nā kūlanaʻelua oi papakaukau li nui, suppuration o kaʻeha, infiltration o pathogenic koʻohune i loko o kaʻili malalo papa.

He loaʻa i kekahi mea o ka Kāohiʻana?

Eia naʻe,ʻaʻohe mea i maopopo loa no ka pale i na maʻi like bullous pemphigoid une lōhai. Maoli ai, ia mea nui, eʻimi i kōkua i ka manawa, a me ka maʻi ahulau, a hiki i ka manawa o ka pili maikaʻiʻana Pono e akahele kanaka hoʻoponopono i ka moku'āina o ke ola.

Mai poina i ka maʻi ma ka lapaau ua manao like kekahi ikehu Ka maʻi 'aʻai peni mäka. Ia mea ke kumu i ka alo o ka maʻi i ka hoʻomanawanui pono undergo i ka hulina ninaninau e hōʻoia a noho aliʻi mai i kaʻike, o Cancer. E hoomanao i me kekahi maʻi ka nui maʻalahi e Makuakane ina oe hoʻomaka lapaau kakahiaka.