'O ka lipid peroxidation (LPO) he pilina pa'a ia i ka hāme'a ma muli o ke kahe. 'O kāna hana nui,'o ia ke ho'ololi i ka lipids o nā membrane pūnaewele.
I loko o kahi kanaka olakino, ke ho'omalu'ia nā hana o ka lipid pero e ka mea i kapa'ia he antioxidant pūnaewele e ho'oponopono ai i ka lihi a me ka hana o phosphorylation ma o nā mea ho'onāukiuki a me ka ho'okū'ole'ana i ka nui o nā peroxides e pale ai i ka ho'onui'ia o nā huahana hopena o ka hanu. Hiki ke ho'oikaika i ke ka'ina hana palekana hiki ke lilo i kahi ho'omaka i nā hana pathophysiological i ka nui o nā ma'i. 'O kēia ka'ina hana ka papahana o ka enzymatic a me ka'ole enzymatic autooxidation.
Nā'ano
Ho'oponopono'ia ka enzymatic oxidation e ho'ololi i ka bilayer phospholipid o nā membrane pūnaewele. Eia hou, ka mea, ua komo i loko o ke kahua o biologically hana waiwai, detoxification, metabolic reactions. 'O ka ho'onā'ana'ole-enzymatic e hō'ike iā ia iho he mea hopena i ke ola o ka pū. Ma muli o ke kūkulu'ia'ana o ka lehulehu o nā radical free a me ka ho'onui'ia'ana o nā peroxides, ua emi iho ka hana o ka pūnaha antioxidant a, no ka mea, ua'ike'ia ka make o ka mea ola.
'O ka LPO
No ka ho'omaka'ana o ka lipid peroxyidation, ke kū'ana o nā radical oxygen li'ili'i, ma muli o ke kūlana o ka ikehu ki'eki'e he koho pono'ole. Ma hope o ka pakele'ana o ka mole, ua ho'okumu'ia kahi superoxide o ka oxygen, a me ka hamo'ia me nā hydrogen atom, e huli ana i ka waipiha peropika. No ka mālama'ana i ka nui o ka superoxide i loko o ke kele, aia kahi superoxide meli e lilo ana i ka hydrogen peroxide, a'o catalase a me peroxidase e ho'ohemo i ka wai. Inā'ike'ia kahi meaola ola i ka ho'onāukiuma'ana, e pi'i nui ka nui o nā radical hydroxl free. Hiki i ka oxygen hydroxide a me kona mau'ano hana like'ole e hiki ke hana ma ke'ano he po'e ho'okomo i ka hana o ka peroxidid lipid.
Ho'ohana'ia nā hua'ōlelo o ka lipid peropili e ke kino a ho'ohana'ia paha no ka hō'ailona o prostaglandins (nā mea i loko o nā kinona inflammatory), thromboxanes (i komo i loko o ka hopena o nā hanana ho'ohālike o ka thrombs), hormones adrenal.
'O ke ka'ina hana
Ma muli o ke'ano ma'amau o ka membrane pa'akikī, hiki ke loli ke ka'ina, ka hana, a me ka nui o nā huahana i loa'a i nā mea i loa'a. No ka laʻana, i ka ha awina o lipids peroxidation luna kahi a kekahi hapa o ka halepaahao paia ua Kīwala'ō unsaturated momoma nāʻakika, a me ke kua'āina, ina ke kumu o ka COP ka naʻokoko. Eia kekahi,'o nā enzymes i ka mea ma'amau ka mea e ho'onohonoho ana i ka nui a me ka loli o ka ho'okumu'ia o nā oxygen li'ili'i'ole, a me ka ho'ohana'ana i nā peroxides. 'Oiai ma ka hopena o ka hua'ōlelo lipid, nā mea e pili ana i ka lipid composition o ka membrane pūnaewele a me kona ho'ololi ho'ololi'ole e like me ka pono o ke kino. 'O kēia mau mea he mau hua'aina E a me K, thyroxine (thyroid hormone), hydrocortone, cortisone a aldosterone (ma ka mana'o o ka pane). 'O nā kinona uila,'o ka lā'au C a me D. ke ho'olālā nei i ka paia o ka hale.
Ka Ho'omaka Hana
Hiki ke hō'ili'ili'ia nā huahana me ka lipid peroxidation i loko o nā'opa a me nā wai o ke kino inā'a'ole hiki i ka pūnaha antioxidant ke kū'ai aku iā lākou ma ka uku i makemake'ia. 'O ka hopena, ua ho'opau'ia ka lawe'ia'ana o ke kinona ma loko o ka membrane pūpū, e hiki ke ho'opili'ia i ka mea i ho'ohui'ia i ka māmā o ka mahele wai o ke koko, ka hapa o ka polarization a me ka depolarization o nā membrane cell muscle (e ho'ohaunaele i ka hawewe'ana o nā pulupulu pūnana, 'O ka hō'ailona o ke koko, ka hō'ino'ana i ka pale koho). Eia hou, i ka papa kuhikuhiE huahana o lipid peroxidation, ma hope o ka moʻo o biochemical reactions, i hoohuliia mai i ka aldehydes, ketones, nāʻakika, a pela aku, kēia mau waiwai i kaʻawahia ia ma ke kino, i hoike mai ai ia ia iho i loko o ka ka ho'ēmiʻana uku o ka DNA hoʻololi kemikala, hoonui capillary permeability, mahuahua oncotic puʻe, e like me 'O ka hopena, kahi ma'i-'aha.
Nā hō'ike i loko o ke ke'ena
Ma muli o ka ho'onui'ana i ka nui o nā radical oxygen li'ili'i he hopena'eha'eha ma ka paia o ka hale, a ho'opau i nā hua o ka mea kanu me ka ho'omau'ana o nā meaola nucleic, a pēlā ho'i i ke kino o ke kino, he kumu pathopysiological ia i ka ho'omohala'ana i kekahi mau kumu ma'i. 'O ka pono o ka lipid peroxidation he mea nui ia no nā ma'i o ke ake, a me nā hui, nā ma'i palupalu, nā ma'i hemodynamic, nā ma'i o ka lolo, nā'eha a me nā ahi. 'O ka LPO kekahi o nā kumu i ka ho'omohala'ana o atherosclerosis. 'O nā mea ola ma'amau, ka hana'ana i ka cholesterol a me kona mau kinona kaumaha li'ili'i, e hana i nā hua e hō'ino ai i ka pāpuni. I kēia hihia,'o ka hopena o nā'ano hana ma'amau āpau e pili ana i ka ho'one'e'ana i ka pō'ino e hopena. 'O kēia ka mea e ho'āla ai i ka'ōhūpopo, ka ho'ohui'ia'ana o ke koko i loko o ka lumen o nā moku li'ili'i ai'ole i ka pilikino'ana i ko lākou mau paia. 'O ka hopena, ke lohi nei ka ne'e'ana o ke koko ma kēia wahi, no ka mea, ua lilo mua ka lumen o ka moku. Ho'onui kēia i ka ho'onui'ia'ana o nā kikoo koko. Ka loa susceptible i na loli ma ka coronary arteries, ka aorta, hoikeia ma ka? Aaieou symptoms o coronary mai o ka naau.
Nā hana palekana
Pono ka po'e loiloi e ho'omana'o i ka ho'okō'ana i nā ka'ina hana hō'ailona a me ke olakino e hiki ai ke ho'ololi i ka hana o ka peroxidid lipid. Pono e mālama i kēia mea i ka mea ma'i. Ma ka hoʻonāukiuki kumumea nā pāhawewe Inc (no ka maʻi 'aʻai), ultraviolet malamalama (me rickets, hoʻoʻino maʻi o na sinuses, antibacterial lapaʻau lumi),ʻume mākenēki kihapai (MRI, HI, physical Inc) kau ma ka hyperbaric keʻena (ma ka poliomyelitis, kiʻekiʻena maʻi).
'O ka palekana a me ke kāohi
'O nā mea hana i nā lumi'oni ray, nā kahu hānai a me nā kahu hānai, nā kānaka lapa'au physiotherapy, nā kānaka pi'i, nā kānaka me ke kino'ole e'ai i nā mea'ai e loa'a ana i nā mea'awa'aha: i'a, ha'alulu ai'ole'aila'oliva, greens, eggs, green tea. Ma waho a'e o ka ho'ololi'ana i ka'ai, hiki ke ho'ohana i nā lā'au lapa'au i ho'opa'a i kekahi mau hui o nā radical free ai'ole e hui pū me nā metal o valence pa'akikī. No laila, pani lākou i nā molecuka li'ili'i o ka oxygen hana, me ka'ole e'ae iā lākou e nakinaki i nā mea hō'emi LPO.
Nā diagnostics
Ma ke kuhi o ka ho'omohala'ana i nā ho'okolohua ho'okolohua, hiki iā mākou ke'ike i nā peroxides i loko o nā kino o ke kino kanaka. E hana i kēia, e lawe mai fluorescence microscopy. E kau wale, e'ike i ka peroxidation lipid. 'A'ole pono ka wehewehe o kēia ho'ā'o diagnostic. Ma hope o nā mea a pau,'o ke kumu o ka nui o nā ma'i,'o ia ka hana nui o ka lipid peroxyidation. 'O ka'ike'ia o kēia'ano e ho'oholo i nā'ano o ka lā'au ola.
Mai ke kuanaʻike o ka mea maʻamau physiology o lipid peroxidation mea e pono ai ke kahua o steroid hormones, hoʻoʻino uao, cytokines a me thromboxanes. Akā ke pi'i ka helu o nā huahana o ka hō'ailona hō'ailona kalapili i ka waiwai i'ae'ia a me nā peroxides e ho'opō'ino i nā'ano pūnaewele, e ho'ohaunaele i ka inoa o DNA a me nā protein,'o kahi'ōpili antioxidant e ho'emi ana i ka helu o nā radical oxygen li'ili'i a me nā kinona uila me ka loli pa'akikī e komo. Eia hou, ho'onui i ka inoa o catalase a me peroxidase e ho'ohana ai i nā surpluses o nā peroxides a me nā huahana o kā lākou holomua.