PTH, a mahuahua nui - i mea e hoikeike ma ke Ka Ikepili?

Parathyroid hōmona (ole kapaia parathyroid hōmona, parathyrin) - ka hōmona hua mai la ia e ka parathyroid'aʻaʻa (parathyroid) glands, a i aia ma kaʻaoʻao anterolateral o ka'ā'ī. Ka mea, i ke kua o ka thyroid gland, i mea pili loa e pili ana i ka hope luna o ia mea, a me ka haʻahaʻa o nā kona kaʻana like 'ana. Parathyroid hōmona i loko o kā lākou Nine Inch ano o ka luna 'kumuʻiʻo substance - polypeptide'aminoʻakika nā mea loaʻa.

Kona papa kuhikuhiE kuleana pili i mea e komo a me ka hooponopono ana o kalipuna, a phosphorus pūnao i loko o ke kino. Ka maʻiʻo o ke kalipuna i loko o ke koko a me ka secretion o parathyroid hōmona e 'ana e kaukaʻi mai kekahi i kekahi. Ka hōmona ke hoonui i ka kalipuna lehulehu ma ka hana ma ka iwi'aʻaʻa, hakuʻala a me gastrointestinal'āpana. Ka iwi parathyrin maoli he logoff mea hoʻoheheʻeʻia i ka mea pōhaku 'ana ma ka noho haumāna kahi hoʻololi kemikala o ka ho'ākāka' ia i nā'ūhū i nā kuleana no ka hālāwai hope o ka iwi mea. Iwi'aʻaʻa ua malalo iho ma lalo o ka aoao o PTH resorption a me ka kalipuna Ion i aia i loko o ke koko. Together me ka kalipuna mail paratgormot kōkua e hooponopono i ke kiʻekiʻe o ka posapahate i loko o ke kino. Hoemi i ka nui o ka mea mua liluwelo kaʻina, ia amplifies ka lua pele. A, i ka hōmona ua limahana ma ka 'ō hoʻololi kemikala o calcitriol i loko o ka naʻau liʻiliʻi, e kōkua kalipuna reabsorption. Parathyroid hōmona i kaʻauhau'ēʻaʻe loa i loko o ka rula o na hana o nā mea a pau kalipuna-e kaukaʻi nā'ūhū katalirizuemye lākou naoh. Ma lalo o kona mau keiki i loaʻa i ke koko coagulation nenoaiu.

Inā PTH ua kiʻekiʻe, laila i hanaʻia loa endocrine mai pili me ka iwi ano hoopono kue - hyperparathyroidism, a me ka osteoporosis. I ka hopena o ia physiological kina ikaika emi i loko o ke koko kalipuna pae, i hiki aku ai i māhuahua neuromuscular excitability. Comorbidities ma keia hihia hiki ke hookauwa na kiʻekiʻe mekala 'åkilikai ka maʻiʻo ma ke kino a me ka hooulu ana o kaʻaʻa puʻuwai ole. Ma ka hoemi i ka maʻiʻo o ke kalipuna i maka aniani cataract maka ia lŘlŘ.

Pae o ka hōmona o ka parathyroid glands i loko o ke koko mea malalo i ka circadian pāpana. Ke basal ilikai Ua waiho ma kahi o 8 am, oiai ma ka 14-16 hola o ka lā, i ka wa a ke kanaka mea ma ka piko o ka ha awina, parathyroid hōmona mahuahua. ke koko ho'āʻo ua lawe mai ma ka helu o ke parathyrin immunohemilyuminestsentsii. Ua pono e ka nele opu, a me ka lā 'ole mau ma mua koko mea hōʻikeʻikeʻuʻuku hoʻopau waiʻonaʻai ana, a kaumaha hoʻokō no kekahi mau hola ma mua o ka kaʻina hana, i ka uahi.

Ma Ka Ikepili o parathyroid hōmona ua hoakaka ia wale nō ka wā o ka hoomanawanui ka mahuʻi wale i ke ola ana o ka maʻi e like me hyper- a me ka gipokaltsimiya, urolithiasis a me ka neurofibromatosis. Nō hoʻi nāʻikepili no ka Ikepili mea i loaʻa: osteoporosis psevdoperelomy iwi lōʻihi, i kekahi physiological hoʻololi osteosclerosis iwi a vertebral kino a me kēia mau endocrine neoplasia type 1 a me ka 'ano 2 (kanaka 1.2). Ma parathormone uku no ka makua ua noʻonoʻo 9,5-75 pg / ml. Ua pili i nā kānaka a me nā wāhine o reproductive makahiki. Inā ia akulla 'i ka PTH ua ke kiekie, he mea na kumu, e kuhi ana i ke ahonui loaʻa iniiaiie, kiʻekiʻe, tertiary hyperparathyroidism, pseudohypoparathyreosis a Zollinger-Ellison maʻi pale.

Ma lalo o ka hui iniiaiie hyperparathyroidism hyperplasia o ka parathyroid gland, Ka maʻi 'aʻai o ka prostate'aʻaʻa a me ka endocrine neoplasia mau ano. Co. haumāna hyperparathyroidism nā maʻiʻaʻa puʻuwai insufficiency, hypervitaminosis D, ulcerative colitis, rickets, Crohn ka maʻi. Inā PTH ua ke kiekie, alaila, i ka Ka Ikepili ua ana hana i loko o ka huipūʻana me ka ho'ākāka 'ana o ka nui o ke kalipuna i loko o ke koko, a me ka wā e hiki mai ai ka hoʻohālike o nā nā hoailona, a kuhikuhi mau panalaau.