Uku aku: He aha kēia? DNA? Aiiio maomeka

Uku aku - he ola aeea waiwai, e hana me keʻano o ka DNA ka pōʻino. I ka mea ma waho ao nei, ua nui aʻe i hiki i irreversible loli i ka noho ana meaola. E hookoe i ko lakou ano hoopono, e pale aku pathological mutations a incompatible me ke ola, he pono e he ano o ka hoʻoponopono-ke ola. E like me ka mea hana kue i ka pono o ka aaiaoe mea o ka halepaahao? E hoomanao i keia ninau i hou au mamuli. No hoi, huli mai mea mau i ke kino o ka hoʻoponopono maomeka, a pehea e hana.

Abnormalities i loko o ka DNA

hiki e wāwahi Deoxyribonucleicʻakika lātoma i loko o ka papa o ka biosynthesis like hoʻi me lalo o ka aoao o nā palapala 'ona. Mawaena o ka hopena maikaʻi aʻe, i loko o 'ana, loaʻa ke ana wela a me ke kino ikaika o kekahi kumu. Inā ka fracture ana, o ka halepaahao uku aku kaʻina kānāwai. Penei ka helu kuhi puke i ka hoihoi hou ia ana o ka palapala 'ole o ka DNA lātoma. No ka uku aku e halawai pu me kekahi'ūhū pono a pau o ia mau makana i loko o na keena. Mai ka hikiʻole o ke kanaka keena, e lawe mai i kekahi ke ola hou pili maʻi. Ka 'epekema e Pilikanaka na keʻano o ka hanaʻana o ka hoʻoponopono, - ka kālaimeaola. I loko o ka hahau lawe mai i ka puu o ka ho'āʻo a me ka ike maopopo ana, ka hoʻopiʻi no i ka mea i hiki i ka maopopo i ka ke ola kaʻina. It E e hoʻomaopopo i nā maomeka o ka DNA? Aiiio e loa hana hoihoi, e like me ka mōʻaukala o ka loaʻa a me ka hoʻopaʻa 'ana i kēia kŰia. He aha kumumea he hoʻonui i ka hoʻomaka o ke ola? E hoʻomaka i ke kaʻina hana, e mea pono ia DNA stimulator loli'aʻaʻa? Aiiio. He aha ka mea, oi hōʻike ma lalo nei.

Mōʻaukala o ka Kaka

Ua kahaha ko oukou naau kŰia hoomaka Amelika nä känaka 'epekema Kellner këia. Ka mea mua nui loaʻa ma luna o ka hele ana o kaʻimi loa i ka lewa? Aiiio ua lilo ia i kŰia me photoreactivation. Kēia kau Waiter kapa ino ka ho'ēmiʻana kanawai o UV irradiation a me kia-ino poino aeea huali kahawai o ka malamalama o ka hiki pae pāhawewe.

"Light ke ola"

Hope Haʻawina Kellner loaa kekahi Logical hoomau i loko o nā hana o 'Amelika biologists Setlou, Rupert a me kekahi mea e ae. Mahalo i ka hana ana i keia pae ana o kānakaʻepekema i ua reliably hookupaa ia photoreactivation mea he kaʻina hana i ua hoʻomaka 'ana ma kekahi kūikawā waiwai - he'ūhū e catalyzes ka cleavage o thymine dimers. Ka mea, o ka mea nana, e like me ka mea huli mai, i hana i loko o ka papa o nā hoʻokolohua ma lalo o ultraviolet malamalama. Pela he kukui hiki malamalama a hemo hana o ka'ūhū, i hoʻolaha cleavage o dimers, a hoihoi aku i ka palapala ana o ka poino'aʻaʻa. Ma keia hihia mākou e kamaʻilio e pili ana i ka malamalamaʻano o ka DNA? Aiiio. Mākou i hoakaka ia oi maopopo. Mākou ke olelo aku i ka malamalama? Aiiio - ua hoihoi hou ana i ka palapala olohelohe ia lakou i ka malamalama ma hope o ka 'ole o ka DNA ka pōʻino. Naʻe, i kēia kaʻina ua ole wale ka hoʻopukaʻana i ka hoʻopau o ka hewa.

"Dark" ke ola

Kekahi manawa ma hope o ka puka ana o ka malamalama i 'akomi i pouli? Aiiio. O kŰia ia lŘlŘ me kekahi kanawai o ka malamalama na kukuna o ka hiki pae. Kēia resilience i loaʻa i ka hoʻopaʻa 'ana i ka pā lonoaʻili o kekahi koʻohune e ultraviolet kukuna a me ka ionizing pāhawewe. Dark? Aiiio DNA - i ka hiki ana o keena, e wehe i kekahi pathogenic loli deoxyribonucleicʻakika. Akā, e pono e olelo mai i keia mea,ʻaʻole he photochemical kaʻina hana, ma ka Akä naÿe i ka malamalama ke ola.

Keʻano papa hana o ka "pouli" poho Cleanup

Loina o ka koʻohune hōʻike ia ma hope o ka kekahi manawa ma hope o ka hookahi-aa? Meaola loaa i kekahi hapa o ka ultraviolet, kūpono ai i loko o kekahi mau pauku o ka DNA i poino, o ka halepaahao regulates kona na keʻano o ka hanaʻana i loko o ka kekahi alanui. E like me ka hopena, i ka Hoʻololi 'DNA mea wale i kekahi apana oki mai ka na kaula. Na kūpono hou hoʻopiha i nā wahi i wāhiʻia o ka'amino nāʻakika e pono ai mea. Ma na olelo e ae, e lawe resynthesis o DNA. E wehewehe ana o nā kānakaʻepekema ia mea me ka pouli? Aiiio'aʻaʻa - keia mea i kekahi koe iʻimi ana i ka mea kupaianaha kūlana pale nā mea hiki o ka holoholona a me ke kanaka.

Pehea ke ano o ke kapili'ōnaehana

Ho okolohua Ua hoike na maomeka o ke ola, a me ka loa ola o kēia hiki, i ka hanaia hoʻohana hookahi-aa? Meaola. Akā, ke kapili keʻano o ka hanaʻana i hoʻomaopop 'ana i ka noho ana keena o nā holoholona a me nā kānaka. Kekahi kanaka e ae, mai xeroderma pigmentosum. Kēia maʻi ua kauoha ae la ia e ka nele o ka hiki ana o aeee resynthesize wela DNA. Xeroderma ili. No ka mea? Aiiio kahua? Four'ūhū, i mālama i ke kapili kaʻina - he DNA helicase, -ekzonukleaza, polymerase a me ka -ligaza. Ka mua o kēia mau huina lakou mea hiki ke hoʻomaopopo iho poino i ka kaulahao nā lātoma o deoxyribonucleicʻakika. UaʻAʻole wale ke hoʻomaopopo iho, akā, iʻoki i ka kaulahao ma ka akau wahi, e wehe i ka māhele o ka Hoʻololi 'lātoma. Waiho wehe 'ua lawe mai me ka DNA exonuclease. Next, ka hoʻololi kemikala o kekahi hapa hou o deoxyribonucleicʻakika lātoma mai'amino nāʻakika me ka manao e loa e puku i ka pōʻino, ua make Hoʻohana. Well ua hōʻike i kēia luna 'liluwelo kaʻina hana me ka DNA ligase'ūhū. He kuleana no ka IeIIeYOA i ka poino hapa o ka synthesized lātoma. Once a pau eha nā'ūhū i hana i ko lakou hana, o ka DNA lātoma ua pau loa ia i hōʻano hou, a pau i ka poino o ka mea i hala. 'O kēia pehea smoothly hana maomeka loko ola keena.

Mea Maluna

Ma keia wahi, ua hōʻike 'haumana i ka hahai ana i ke ano o ka hoʻoponopono nenoai. Ua ho'ā 'ia paha ke kaumaha ma muli okoa aʻe. Mau nā:

1. Reactivation.
2. Recombination ke ola.
3. ? Aiiio o heteroduplexes.
4. Excision? Aiiio.
5. Ke reunification o non-homologous welau o ka DNA nā lātoma.

All hookahi-aa? Meaola i ma ka liʻiliʻi loa ekolu enzymatic nenoai. Kēlā me kēia no ia mai ka hiki ia? I ka ke ola kaʻina. Mau nenoai nā: ala, a me ka excision postreplicative. Ka ekolu ano o ka DNA? Aiiio i prokaryotes. Like no ka eukaryotes, ka mea, mea ia lakou, nā maomeka, i ka poe i kaheaia Miss-mathe a me Sos-kapili. Kālaimeaola hookolokolo aku la ia i loko o au mamuli a pau o kēia mau ano o ka hoʻoponopono-hoola ana o ka aaiaoe nā o ke keena.

'Ole hou maomeka

Direct? Aiiio - ka mea, o ka mea liilii loa huikau ala o ka noho pakele o nā hoʻololi pathological i loko o ka DNA. Ua ua lawe mai kekahi nā'ūhū. Mahalo iā ia, i ka hoihoi hou ana o ka 'ole o ka DNA lātoma ka loa e hoʻokēʻai ai. Nui, i ke kaʻina puka mai i loko o hoʻokahi koe. Kekahi o ka mea ma luna o nā'ūhū o O6-methylguanine-DNA methyltransferase. Excision? Aiiio nenoaiu - keia mea i ke ano o ka hoʻoponopono-hoola ana o deoxyribonucleicʻakika, i komo aiʻoki mai ka Hoʻololi ''amino nāʻakika, a mahope hope o ko lākou hou-synthesized hoʻopunipuni. Kēia kaʻina ua lawe mai i loko o kekahi mau kahua o ka hoʻonaʻauao. Ma postreplicative DNA? Aiiio i loko o ka 'ole o kēia lātoma hiki ke hana ia ma kekahi waiwai kaulahao. A laila, paa hou mai la ka mea, me ke komo 'ana o RecA kumuʻiʻo. Postreplicative? Aiiio'ōnaehana mea kū hoʻokahi i loko o ia kona kaʻina nele pae ka loaʻaʻana o pathogenic hou.

ʻO wai lā ka mea kuleana no ke koiʻano papa hana

I ka lā, kńnaka ike ia ia i ka mea a pau, e like E. coli, aole emi malalo o ke kanalima nā'ōewe 'ana no ka hoʻoponopono. Kēlā me kēia'ōewe i kekahi mau kuleana. Mau nā: ka loaʻaʻana, ana, hoʻololi kemikala, IeIIeYOA, 'ike no ka hopena o ka UV kukuna, a no laila, ma luna o. Eia naʻe, i kekahi nā'ōewe, a me ka mea i kuleana no ke kapili keʻano o ka hanaʻana i loko o ka halepaahao, malalo iho o mutational loli. Inā keia hana, a laila, e hoʻolana i oi pinepine mutations i loko o nā keena o ke kino.

Ke noho pilikia poino DNA

Kela lā, i ka DNA o ko mākou kino keena ÷ ino o ke poho a me ka pathological loli. Kēia Ua kōkua ai i nā e? Aneie kumumea like me ultraviolet pāhawewe, ai mea hoʻonui, Nine Inch, wela ihola,ʻume mākenēki kahua, aʻo nui lehulehu e hoʻomaka i ho'ākāka 'ia i keʻano o ka hanaʻana i loko o ke kino, a me ka oi. Inā ka DNA 'ole ua wāwahiʻia, ka mea hiki i loa mutation keena, a hiki ke alakai i ka maʻi' aʻai i loko o ka wā e hiki mai. Ia mea ke kumu i ke kino o ka luna 'o nā ana, e hana me ia nā palapū. E like ina na nā'ūhū e hikiʻole, e hoʻi ai i ka palapala nānā aku o ka DNA, hoʻoponopono'ōnaehana hana mai e mālama i ka hewa a hiki i ka palena iki.

homologous recombination

Mākou e maopopo i ia mea. Recombination mea he wehe aʻe o aaiaoe mea i loko o ka nahā i a me ka hui nā lātoma o deoxyribonucleicʻakika. Ma ka hihia ma laila nō e uhaʻi aku i loko o ka DNA, homologous recombination kaʻina huli no. Ma ka mea, ua ana koena o nā nā lātoma. Me keia pololei hoihoi palapala 'ole o deoxyribonucleicʻakika. anal o ka DNA ke hana ma kekahi mau hihia. Ma ke kaʻina hana o ka recombination mea hiki e hoʻononiakahi i kaʻokoʻa hehee wale elua.

Keʻano papa hana o ka hou ana o ke kino a me ka ola

Ke kapili - ia mea he elue no ka maʻamau functioning o ke kino. Ua hoolilo i kela la i keia a me ka Hawaii olelo hooweliweli DNA poho a me mutations, multicellular 'ole ke hakuloli a ola mai. Kēia ia lŘlŘ kekahi manawa i ka hoʻokumu 'ia ka hoʻoponopono kahua. I ka nele o ka maʻamau resilience ke kumu o ka maʻi mutation a me nā abnormalities. Kēia loaʻa kekahiʻano o ka pathology, oncology a hiki kūnewa iho. Hereditary maʻi aie i ka haunaele o ka hoʻoponopono ke alakai i ka loa malignant hikoko a me nā abnormalities o ka meaola. Ano, i ka hōʻike 'ia kekahi mau mai, kena ae la ia e malfunctioning ka DNA? Aiiio nenoai. Mau mea, no ka laʻana, maʻi e like Cockayne maʻi pale, xeroderma, nonpolyposis AeXIeAaOIePEAaI Ka maʻi 'aʻai, Trichothiodystrophy a me kekahi mau maʻi' aʻai.