Alt māhuahua. He aha e hana ai?

alanine aminotransferase (Alt)'ūhū na ma ke akepaʻa hoʻohana me he anakahi e huai ae kāna hana o kona hana. He aha ke ano o ka mea, ina Alt pae mahuahua?

Ma waena o ka nui o nā'ūhū i nā nā hoailona o hepatocellular kāna hana, i ka loa a me ka pono keia mau mea e pono ai i alanine aminotransferase (Alt) a me ka aspartate aminotransferase (AST). Ma ia hōʻeleu i hoolilo naoh i loko o ka gamma-gamma poe ketoglutarate alanine a me aspartate pūʻulu. E like me ka hopena o kēia kaʻina hua pyruvic a me oxaloaceticʻakika.

A me ka Alt a me AST - ke kelepona hele nā'ūhū hakuʻala, akepaʻa, naau. Eia naʻe, alanine aminotransferase,ʻano nui aia i loko o ke ake, a mea i ka walaʻauʻana o kona anakahi, a me ka aspartate aminotransferase -. E like me ka hapa o ka nui ( 'ē aʻe ma mua o ka poʻe i helu' ia ma luna) o nā loko a me nā'aʻaʻa, a me skeletal Muscle, lolo, etc. kēia mea ke kumu o ka ki'ūhū AST mea emi, he pono ole me he anakahi o ke ake hana, a me ka mea i kuleana i loko o'aminoʻakika pūnao.

Inā he mea e make ai o ke ake keena, naau, hakuʻala, alanine aminotransferase (Alt) i loko o ke koko Falls. Mea ulu o ka ke kelepona hele'ūhū i loko o ke koko haku mele 'ana i ka' latent maʻi. I ka haʻawina hōʻike i kiʻekiʻe Alt pae, e hoʻomōhala mai nō nui i loko o ke koko, e like me:

- cirrhosis,

- mea hoʻomaʻi hepatitis,

- myocarditis,

- ake Ka maʻi 'aʻai,

- naau ole,

- he naau hoouka.

A me ka mea ulu aspartate aminotransferase i loko o ke koko ke alakai i

- naau hoouka,

- ake Ka maʻi 'aʻai,

- muscular dystrophy ,

- pancreatitis,

- paroxysmal myoglobinuria,

- hepatitis,

- dermatomyositis,

- naau ole.

Inā, nae, o ka pono like o ka AST a me ka Alt māhuahua, ma laila e e:

- nui hepatic necrosis,

- toksinogennye ake poino,

- loa mea hoʻomaʻi hepatitis,

- lōʻihi-vascular'opi.

Ua aneane maʻi a pau kanaka koko haʻawina o ka hōʻike i ka mämä a me ka AST, a me ka Alt māhuahua, i ua, i ka nui o nā nā'ūhū i loko o kēia mau hihia, ua kokoke i ka ia, a hōʻike i ke alo o ke pathology. Akā, he mea koe kekahi koena unuhi. Inā Alt pae mahuahua i ka oi loa ma mua o aspartate aminotransferase, i Hōʻike ka incubation au o ka hepatitis B maʻiʻaʻai. Inā i ke koko ACAT nui, ia oi pinepine me ka naau pilikia.

Ma ke ola i ke kanaka i nā mea o kēia mau ke kelepona hele nā'ūhū e ia ma ka pae:

- i loko o nā kānaka i ka 41 iniha, no hano (U / L);

- i loko o nā wāhine i ka 31 iniha, no hano (U / L).

E kuhikuhi i ka nui o kēia mau nā'ūhū, kumuʻiʻo pūnao, lawe koko kemika. Kūmau no ka Alt malaila e 28-190 nmol / (c H) ai 0,1, 68 mmol / (ML HR), a no ka ACAT - 28-25 nmol / (c H) a 0,1-, 45 pmol / (ML HR). Keia rula ua i loko o nā hihia ua haawi mai no ke ano o Reitman-Frankel (colorimetric iaoia o ka noiʻi).

IeAUPIIe, IAa IO, ke koko ho'āʻo ma alanine aminotransferase lawelawe 'ia e aʻo e pili ana i ka moku'āina o ke ake, a me ka aspartate aminotransferase - e ike i ka moku'āina o ka myocardium (naau Muscle). Inā ka Ikepili hōʻike lākou kiʻekiʻe koko, ka mea, 'o ia hoʻi ia na keʻano o ka hanaʻana o ka make a me ke kelepona hele ka make ana i loko o kēia mau nā loko. No laila, ina AST loa kona pae i loko o ke koko i loko o ka 2-20 manawa, a laila ka mea, ua hiki i ka hooulu ana o myocardial infarction. Inā Alt pae nui ae, aia no he pathological kaʻina hana i loko o ke akepaʻa.

Ma lalo o hoemiia anakahi o ke koko alanine aminotransferase a aspartate aminotransferase poe akamai i ike i ka nele i ke kino o ka o ka pyridoxine (wikamina B6). IeAUPIIe, IAa IO kēia ka hana i hāpai keiki, me ka pinepine hemodialysis a me kaʻaʻa puʻuwai 'ole.

Eia naʻe, mai ka koko lāʻau lapaʻau o ke ola i ke kanaka i kēia mau nā'ūhū mea ike ole ia, no laila, i ka i maliu a me kā lākouʻano papa hana o kaʻae (uku o ka mämä holo o ka wai koko lapaʻau, 'ē aʻe bioliquid a me nā'aʻaʻa o kekahi waiwai, no ka lākou redistribution, biotransformation, hoʻopau, mai ke kino).