DNA methylation: he hōʻuluʻulu manaʻo

Methylation ua ka hui ana o kekahi kalapona, a ekolu hydrogen nā'ātoma i kekahi lātoma. O kŰia ua manaoia e ia i ka olelo hope i ola mālama. He ua pu ma ka manaʻo o ke aneane pau loa ke kino.

oihana

Meto pūʻulu (kalapona a me ka hydrogen nā'ātoma) ka pae'āina ma:

1. Ke kino o ka pane i stressful wahi, i hiki.
2. Hoʻomohala a me aaioee o glutathione. Ua hana like me ka kī antioxidant i loko o ke kino.
3. Detoxification hormones, kaumaha i eliiaʻi a me Nine Inch i huiʻia.
4. Kū hoʻoʻino keʻano o ka hanaʻana.
5. Hana hou i poino keena.
6. 'ōnaehana paleʻea pane a me ka hooponopono ana i nā mea hoʻomaʻi a me nā mea palahēhē, e ka mana o T-keena.

. Like nui o ke kaʻina hana o ka DNA methylation. E hoi kakou i ka mea i loko o oi au mamuli.

Epigenetic hoʻoholo o

способствует передаче паттернов следующему поколению клеток при митозе. DNA methylation lauana kōkua ai i nā ka hoololiia ana o ka mea e hiki mai ana o ka hanauna o ko keena ma ka mitosis. KŘpa a nei, ka mea, ua loaʻa i ke kaʻina hana o ka hui ana i nā pūʻulu o nā'ātoma i loko o ka terminally-differentiated hale mai kekahi e pili ana me ke kahua o ka iaiyoe, a synaptic plasticity. K. Miller a me D. Sweet hoʻokolokolo DNA methylation. Këia i ka kŰia alakai ia e manao nei makou, o ka ha awina o ka methyltransferase dezoksiribonukleinovokislotnoy me ka nui loa, a mahuahua nui i loko o na holoholona i memorizing hou ike. Kēia kōkua emi i ka hōʻike o nā'ōewe i uhi i ka hoomanao ana keʻano o ka hanaʻana. Eia hou, nā kākau kuhikuhi i kekahi hou mea. Ke noiʻi hōʻike i ke kumuʻiʻo reelin'ōewe ho'ā hope, ka paepaeʻana loli a me ka synaptic pili 'o Randy' ole i loko o ka pathological papa o ka schizophrenia e loli ai iaiyoe ho okumu. A pau keia ololi ua hoʻoponopono demitalazy-nā'ūhū hoomaopopo ana i ka DNA demethylation (hoʻokuʻu mai i ka meto pūʻulu). Hookupaaia kūʻiʻo hiki aku ai i ka nui o ka hopena. , а также обратное ему явление, играют существенную роль при хранении информации и запоминании. DNA methylation me kekahi o ka epigenetic maomeka, e like me ka inverse kŰia, he nui kūlana ma ka 'ike a me ka pūnaewele iaiyoe pāʻani. Kēia manaʻo i hoopaa ia ma ka hopena o ke ao pae E. Kosta. Ua Ua loaʻa i demitilirovanie reelin a me ka glutamate decarboxylase nā'ōewe hiki ke hoʻoponoponoʻiole liʻiliʻi nā lātoma e ālai ia 'ana me ka laau DNA i loko o ka nucleus. Kēia mau haʻawina hōʻike ole wale i ka manawa kūpono o ka hoʻololi 'ana i na manaʻo e pili ana i ke kahua o ka iaiyoe. является динамическим. Ka mea, i kuhikuhi i ka mea i mua manao paʻa DNA methylation mea hōʻeuʻeu. Hoi, ka mea hiki ke hoʻohana 'ia i loko o Inc.

hiʻona

имеют определенную связь, нельзя назвать новой. Ka manaʻo e iaiyoe a me ka DNA methylation i ka kekahi pilina, hiki ole ke kapaia hou. Ua i mua, ua hoʻokumu conditionality synaptic EYI histone acetylation. Ka mea, nāna i hana i ka iwi ma a DNA ua wahi iho. Acetylation ho'ēmi i kā ka Solomona o ke histone i nukelea nāʻakika. Ua weheʻia ke kōkua o ke DNA a me nā nā polokina pili i, i waena o Alia, a me ka ho'ā hope o nā'ōewe. I mea, o ka histone ha awina atsetilotransferaznaya CREBBP (ka paa kumuʻiʻo), e hana me ke ki Ekolu a ololi neurons i pili i ka hopena o keia kumuʻiʻo ma memorization. A eia hoi, ka mea i hōʻike amplification mau nō ano paʻa i ka hoʻohana 'ana o ka histone deacetylase nā mea kūpale. Ua alakai aku ai i ka hoʻonui o ka histone acetylation.

hypotheses

Sweet a Miller noi i ka nïnau a me ka mahalo i ka histone-e kaukaʻi suppression o ka hōʻike lauana. ? Inā ka mea hiki i ke kūlana ma ka hooponopono ana i iaiyoe pāʻani, e alakai ai i ka ia ia, ina DNA methylation? O kŰia Ua ike kuhikuhi i ke kumu o ka malama ana hanana hulina i mitosis a me ka hale a ho okumu i nenoai. Naʻe, i loko o ka mammalian loloʻoihana mālama pinepine 'methylases, hoʻowahāwahā i ka mea i ka hapanui o na keena e nondividing. Aie i ka mea i ka manaoia kŰia ka poʻea pau e suppression o'ōewe olelo, noiʻi ua hiki ke hoole aku i ka palapala a pahiki methylase a hoʻokonukonu keʻano o ka hanaʻana i loko o neurons.

o kéu nā mea mahuʻi

этого явления в формировании памяти, обрабатывали срезы гиппокампа ингибиторами дезоксирибонуклеинокислотных метилтрансфераз. Sweet a me kona mau nā hoapili ma ka nana i ka methylation o ka DNA, i ka manaʻo nui o kēia kŰia i loko o ke kahua o ka iaiyoe, hippocampal slices ia me nā mea kūpale dezoksiribonukleinokislotnyh methyltransferases. Lakou ike i ka mea, ano ua ālai 'o ka hoʻomaka o ka lōʻihi-makahiki potentiation - ka hoʻoikaika' ana i ka synaptic pili 'o Randy ma muli o ke neuronal haʻawina. Kēia kaʻina kumu i ke kanawai o ke aʻo a me ka iaiyoe maomeka. ʻepekema, Ua hoʻi i loaʻa i nā mea kūpale ua hoʻemi kiʻekiʻe o ka methylation ma ka DNA reelin. Ua kuhikuhi i kona reversibility.

ho okolohua

Hoʻoholo 'ana e hele hou i loko o kā lākou mau haʻawina, Sweet a me Miller hoomaka ae la e kanaka hoʻoponopono i nā hoʻololi i loko o ka methylation kumu i loko o kaʻiole i loko o ke kumu hoʻohālike i loko a holoholona aʻo i ka hui i ka henua me kaʻawaʻawa loa stimuli, ma ka maikai, nawaliwali puu hua palaoa. Hana mana e loaa ana nā mea kūpale, expresses ka manawa kūpono o ke aʻo 'pilikia. E huli lakou ia lakou iho ma kahi a lakou i e e he makau i ke kulana, ka mea, froze me ka nui loa emi ma mua o ka hooponopono ana holoholona.

mea, ua ulu

Pehea methylation ke loli i ka hoomanao ana o kaʻiole? ʻepekema, ua wehewehe keia like penei. Ke DNA mea i hiki mai ka hailona no wale i kaʻai i mea e loli i hui pūʻulu o ka hydrogen a me ka kalapona nā'ātoma. Ma keia manao, ka noiʻi hoʻoholo e pili ana i ke kēia kŰia. Ka mea, aʻo kuhikuhi methylation o nā'ōewe kona kūlana ma ke kahua o ka iaiyoe ua mua, ua i. He Ua mua ia i ka wahi ma luna o ka mea a ke kumuʻiʻo phosphatase iaiyoe keʻano o ka hanaʻana i uhi pū. ua hoʻemi 'aoʻao o ke i ka mea ku pono ia. Ua, hoʻokahi hola o ka hoʻoikaika kino contextual makau methylation kaʻilikai, a mahuahua nui aku ma mua o ka haneri manawa. Ma keia hihia, no ka mRNA pae ma hippocampal CA1 māhele malalo i ka palupalu, akā, statistically nui ka ho'ēmiʻana. Ua hookoia ua loaʻa i loko o ka lolo nona ka o ka holoholona a me ka hoʻohui pū 'ia o ka puu hua palaoa liʻiliʻi i nāʻaoʻao, a me ka pōʻaiapili o ka His. Kaawale, i kēia mau nā makana e ole i kekahi kanawai ma methylation. Alaila, o ka hui pūʻulu ua lawe mai wale nō me ka mea keia e ao ana.

DNA methylation a me ka poe oo hoi

Pilikia o ka makahiki, a me ka nānā aku o ka maʻi 'aʻai o kekahi o ka loa kūkākūkā kumuhana apau loa. Over na makahiki o ka noiʻi, ua? Aaei epekema i keʻano o nā theories a me nā ana hoʻohālike. Eia naʻe,ʻaʻole hoʻi ka manaʻo ma ka manawa 'aʻole i pane pono ia i nā nīnau a pau. Ia manawa, i ka hoihoi nui i loko o ka huli 'ana no ka pāʻoihana o ke ao o ka kūnewa loli ma'ōewe hope. Ma kekahi, kona manao ma ka mea maloko Kumu Anisimov. He mea nui mai i ka hoike ana (hōʻike) o nā'ōewe mea e kaukaʻi, i waena o nā mea a pau, ma ka methylation, i mea e loli i ka uku o ka poe oo hoi. Up i ka 5% o ka cytosine residues o deoxyribonucleicʻakika i e pili ana i nā pūʻulu o kalapona a me ka hydrogen nā'ātoma e lilo 5mTs (5-methylcytosine). Kēia kumu ua manaoia e ia i ka wale a eia i loko o ka DNA o kiekie meaola. E pili ana i nā pūʻulu i wahi i nā kaula makalii symmetrically. I koe 5mTs mau hūnā ma ke kua o ka guanine residues. Ma keia 'ole i kekahi mau hana. Naʻe, ka mea i pono, e hoailona oukou ia methylation mea hoʻomau ana ma ka rula o ka'ōewe hope. Loli i loko o ka papa o ka hui ana i nā pūʻulu ua kena ae la ia e hoʻolako 'ole i loko o ka nui o ka EKOLU.

kumu

Makahiki-demethylation i ho'ākāka 'ia ma mua i loko o 1973. Ua' akomi i kēia koena unuhi degere o ke kaawale ana o ka pūʻulu me ka iole nā'aʻaʻa. Ma ka lolo, demethylation hele oi 'Imi ma mua i loko o ke akepaʻa. Ua Ua a laila paa 5mTs emi me ka makahiki i loko o nā maʻiʻaʻai, like hoʻi me fibroblast ili me ka ho okumu. Ke noiʻi? Aaeaaaaony i ka makahiki-demethylation predispose aeee i malignant hou '. O kŰia hiki ke hoike i na mea hua'ōlelo like penei. An AEeOEXAaI'ōewe i huiia i meto pae. Ma lalo o ka aoao o ka Nine Inch reactions hele ma kona disconnection. Alaila, o ka'ōewe ua ho'ā '. Group hanaʻia o ka mana o nā'ātoma kaula hō'ā. Ka uuku o ka helu, o ka oi differentiated keena, a pela mua ma mua o lākou hou - no laila ia mea kaikaina. Ua hoʻomano hoʻohana A Classic kumu hoʻohālike i loko o ka moʻokalaleo, hiki ka hopena i loko o ka ulu ana o kekahi mau? ueo o Salemona. A kŰia o ko lākou mau loa kokololio make koke ma hope o spawning. Nehinei nō opiopio kanaka o reproductive makahiki e make i loko o ka pōkole manawa. Ma ka liluwelo kumumanao, keia kŰia ua hōʻeleu i poe oo hoi, a ua hele pu me ia e nui-me ka unahiʻole DNA demethylation.

Pehea e kōkua i ke kino?

He mea likeʻole ano ma i, e hoʻoikaika 'innate DNA methylation. Mawaena o ka loa hanohano e e kapaia:

1. Ai hawaiian greens. leafy ka lau i poe paipai. Ka mea hana e like me ke kumu o folicʻakika pono e hōʻoia 'kupono methylation.
2. Nā wikamina B12 a me B6, riboflavin. Lākou mau kumu, he hua paha, ka iʻa,'alemona, walnuts, asparagus, a no laila, ma luna o.
3. E loaa ana i ka lawa nui o ke kiniki a me ka makanekiuma. Ka mea, i ka hoʻoponopono methylation.
4. Komo probiotics. Ka mea, he hoʻonui i ka makaukau a me ka omo o nā wikamina B pae a me ka folic i-oe.

Ua mea i nui ke kń stress, e hāʻawi mai hoʻi i ka hewaʻano (waiʻona hokii, e uwahi ana). E e lawe mālama ai i ole i ke kino i kiʻi i kaʻawahia waiwai. Mau hui lawe meto pūʻulu ukana ake.