Hla i kikokiko ai

Ke urgency o ka pilikia e like me miscarriage a me ka infertility, ua manawa increasingly e ulu ana. Hoʻohuikau o ka functioning o ka reproductive nā loko o ke kane a me ka wahine wahine nenoai alakai i like Hui Pūʻia.

Mawaena o na kumu o ia i nā hanau mā, a loaa (nā mea palahēhē, kāna hana o ka endocrine mana, immunological pilikia). Lilo pathological olelo pinepine pane i ka lapaʻau, i mea ole ka innate (genetically) loli.

Currently, ka hoʻomaka koke ka ulu 'ana i kūpono o ka loko o lūmaua fertilization, akā, i kēia iaoia mea,ʻaʻole mau pono, a kākaʻikahi paka i ka makemake hopena.

I kēia lā, ua papapau pu na kānakaʻepekema i ka hapanui o ka hoʻolako 'ole i loko o lūmaua fertilization mea he HLA-like. HLA-incompatibility nenoai noho male hiki aku ai i ka gestosis i hāpai keiki, mā hanau, noho'na makaainana i ulu abortions a me infertility maoli wahine.

HLA-nenoaiu he mea'ē, ma mua o ka histocompatibility antigens, i nā kuleana no, 'o ka mea kanaka kino a me kona mau nā'aʻaʻa a me na keena.

Ma ka hihia ma ka 'akomi i kue o ka antigenic haku mele' ana o ke kanaka keena, keʻano papa hana ua triggered lākou'ōnaehana paleʻea luku ('ōnaehana paleʻea muli o). I na antigens hua mai la ma ka like nā mea'aʻaʻa, a wehe i "e kue ana" keena.

Kekahi HLA-helu kuʻina'ōewe hoʻohui pū ono o chromosome

Kēlā me kēia o nā nā'ōewe he nui kona okoa ana (alleles).

HLA-i kikokiko ai ua hana e hooholo i ka histocompatibility nenoaiu. He ka 'ike o nā alleles (Lolina) a me ka mea i ka hopena o ka i kikokiko ai.

All antigens hiki ke maheleia i loko o ka papa kuhikuhiE papa elua. Ka mua iloko ona i kakauia i ka ili antigens o na keena, ai ka lua o ka - antigens i hiki mai ma luna o ka halepaahao ili honua e komo ai i loko o immunological reactions (ʻaneʻi nō: B- a me T-lymphocytes, macrophages, monocytes, dendritic aeee).

HLA-i kikokiko ai ua hana ma o ka hoike ana mai o na wahine. I waena o ia mea:

- miscarriage,

- infertility a me nā pathological rula pili me kaʻole nā'ōlelo.

Maʻamau, i ke keiki e loaʻa nā maternal a me ka paternal nā'ōewe, e hooholo i ka haku mele 'ana o ko lākou mau nā mea'aʻaʻa.

Pathological mea like me kaʻoi discrepancy (koena unuhi) nā mea'aʻaʻa, a me kā lākou 'aoʻao o similarity. Ma ka hihia mua, kino i ka makuahine o ka hoʻomaka e kaua aku i ka malihini fetus keena, oiai o ka lua - kino o ka wahine ka 'aʻole i ike i ka hāpai keiki iho.

HLA-i kikokiko ai o nā mākua paa ma ka lua o ka papa o antigens ('ōnaehana paleʻea kuleana no ka ha awina). E hana i kēia PalekanaEND_LINK manipulation mea pono e hana i ka pa o ke koko, mai ke aa koko o ka hoʻomanawanui. A laila mālama 'ia e auaaeaiea o ka lāʻau lapaʻau leukocytes. HLA-kikokiko i ka hoʻohana 'ana keʻokeʻo koko keena no ka? Iecaianoaaiiie o ka polymerase kaula naoh.

Ma ia hihia, ka wā aia no he similarity ma waena o phenotypes (ma o HLA), e paʻa ana i ka makuahine immunization Inc kiaʻana i kāna leukocytes kane (ka makua kāne o ke keiki). Eia kekahi, immunotherapy ua lawe mai ka hoʻohana 'ana i ka immunoglobulin. A pau kēia mau 'ana i kūpono e ka mea hiki, e haʻalele i ka 'ōnaehana paleʻea'ōnaehana o ka makuahine, a me ka hoʻoulu kona kupono functioning.

Penei, HLA-e kikokiko i keia la ua lawe mai i loko o ka hanana o nāʻikepili o ka 'aʻe' ana i nā'aʻaʻa histocompatibility makuwahine a me ke keiki. I ka hana o keia PalekanaEND_LINK iaoia i 'ae' ole wale, e hooholo i ke kumu o ka miscarriage a me ka infertility, akā, no ka hoʻomohala, a hoʻokō i ka pau huahelu o pākōlea kāu kiʻina hana a me nā 'ana i kūpono no ka holomua iapaau ana o kēia mau pathological ana.