T4 (free): ke ku'una. Hormone T4 (free): he ho'ā'o koko no nā hormones thyroid

O ka nui i loko o ka maʻamau functioning o ka thyroid gland o ka hypothalamic-pituitary thyroid nenoaiu. Hā'awi ia i ka mana ma luna o ka ho'omau'ana, ka hana a me ka hana o nā hormones thyroid.

Nā'ike nui

Ho'oka'awale ka hypothalamus i ka TRP (ka mea ho'oku'u pā'ani). Ia, ma ka huli stimulates ke kala a me ka hoʻololi kemikala o thyrotropin (TSH - TTG). Ho'omaopopo'o TTG i nā hana e pili ana i nā mea steroid. 'O ke'ano, ho'onāukiuki ia i ka'ikele'a, ka hō'ili'ili'ana, ka pilikino a me ke'ano o ka triiodothyronine (T3) a me kāuroxine (T4). 'Oi aku i ka 99% o kēia mau steroid'elua e puni i ke koko i loko o ke'ano e pili ana i nā pūnaewele lawe. 'Ekahi mau hapa'elika i koe i ka puka noa. 'O ka laulā o ka mea hauā hauā'ole i ka hapanui o nā kānaka ua pili pū me ka'ano hana o ka pākeke thyroid.

Nā hua o kouroxine

'O ka hormone T4 (free) ka mea e ho'onā ai i ka ho'onohonoho'ana i ka ulu'ana a me ka ulu'ana, e mālama pono i ka mahana o ke kino a pēlā e mālama ai i ka ho'omehana wela. Ho'ohui ka pūpū i nā kaupae a pau o ka hāme'a o ka'ōpalu, ma kahi hapa - ma nā huapona a me ka lipid metabolism. 'O ka hormone T4 (free) he mea nui ia o ka ulu'ana i nā wā prenatal a me nā lālani. 'O ka ha'ina o ka hui e hō'ike i kahi pilikino o ke kūnanei, no ka mea, hiki ke ho'ololi'ia ke'ano o ka nui o kāu hua'ōlelo thyroxin e nā ma'i i loko o ka hana thyroid a i'ole ka ho'ololi'ana i ka helu o nā mea ho'omalu kai. I loko o ka lā, ua ho'onohonoho'ia ka helu ki'eki'e o ka steroid a hiki i ka 8 a 12 mau hola, a i ka palena iki mai 23 a 3. I loko o ka makahiki, hiki ke ki'eki'e loa o T4 (free) mai Sepatemaba a Pepeluali, ka palena iki - i ke kauwela. I ke kau'ana o ka manawa (i ka wā o ke kōkō), pi'i ka ho'onui o kouroxin, a hiki i kahi paepae ha'aha'a i'ekolu mau kau. Ma loko o ke ola holo'oko'a,'o ka nui o kouroxin i loko o nā kānaka, me ka nānā'ole i ka moekolohe, e mau mau. Ho'ohālikelike'ia ka emi'ana o nā kūmoho hormone ma hope o nā makahiki he kanahā.

He aha kāu e'ōlelo ai i ke ki'eki'e o kouroxin?

Inā kūpono ke ki'eki'e'o T4 (the free), laila ua mana'o'ia kēia he hō'ailona o hyperthyroidism. Ho'olilo'ia ke kuhi kiko i ka hypothyroidism. 'O ke kū'oko'a o nā ma'i steroid mai kou thyxx-binding globulin e hiki ai ke ho'ohana ia mea he hō'ailona diagnostical pono. He mea nui loa kēia ma nā kūlana i hele pū me ka ho'ololi'ana o ka laulā o thyroxin-binding globulin. 'O kēia mau mea,'o ia nō ka lawe'ana i nā laikini (oral), ka hāpai'ana, ka loa'a'ana a me ka arogens ai'ole estrogens. Ho'ololi'ia nā loli no nā kānaka me ka pilikino pilikino i kahi ho'onui a emi'ana paha i ka mahele o globulin. 'O ka hā'awi'ana i ke koko e ho'oku'u i ke kuhi T4 ua'ōlelo'ia no ka hō'ailona o ke kula ki'eki'e hypothyroidism no nā ma'i o ka hypothalamic-pituitary level. I kēia hihia,'a'ole e loli a ho'onui'ia ka'olu'olu TSH. Ma ke'ano he kaulike, hiki i ka pi'i'ana o kāu mau thyroxin ma muli o ke ki'eki'e o ka nui o ka bilirubin, ka momona, a me ka ho'olālā'ana o kahi māka'ika'i. 'O ka li'ili'i (free)'a'ole ia e loli i nā ma'i nui,'a'ole pili i ka hana hana thyroid. Hiki ke emi ka nui o ka nui o kāu thyxxine.

Ho'omākaukau no ka noi'i'enehana

Ma ho'okahi mahina ma mua o ka hā'awi kālā, ho'oku'u'ia ka hormones (koe ke loa'a nā'ōlelo kūikawā mai ka endocrinologist). No'elua a'ekolu paha mau lā ma mua o ke kahakaha'ana, ua ho'opau'ia ka ho'ohana'ana i nā lā'au'alodona. Pono e lawe'ia ke koko ma mua o ka hana'ana i nā noi'i X-ray e ho'ohana i nā mea'oko'a like'ole. Ma ka'ewa o ka hā'awi'ana i ke koko, pono'oe e kāohi i ka ho'oikaika kino'ana, e ho'oka'awale i nā pilikia ko'iko'i. Ma mua o ka ho'okolokolo'ana, no ka hapalua hola, e ho'omaha'oe, e ho'iho'i mai i kou hanu'ana i ka ma'amau. Ho'opuka'ia ka ho'opuka'ana ma ka'ōpū'ōpū. Me ka'ai hope loa e lawe i nā hora he'ewalu (akā'oi aku i 12 mau hola). Mai inu'oe i ke kofe, wai, ai'ole ka ti. Hiki iā'oe ke wai wale.

Ho'oha'aha'a i kou kūlana o kouroxine

hiki ke hoemi i ka postoperative wā, ka wā o nā haumāna hypothyroidism (li nui o ka pituitary, tireotropinome, - 4 (noa) (9-19 pmol / H maʻamau na wahine a me na kanaka) maʻi pale, Sheehan). Ho'okomo'ia ka ho'onui o ka ho'ona'auao ma ke kumu o ka lawe'ana o ka anabolic, thyreostatics, antionvulsant drugs, ho'omākaukau hana lithium. 'O ke kūlana o kouroxine e emi iho ana me ka ho'ohana'ana i nā mea lapa'au waha, octreotide, methadone, clofibrate. 'O nā kumu kūpono e pili ana i ka'ai me ka hapa nui o ka protein, ka nele o ka iodine, ka ho'ohana'ana i heroin, me ka pilina. 4 (noa) i e hoemi me tertiary (nā aʻalolo hypothalamus TBI), loaa, congenital hypothyroidism (amid nui resection o kaʻeho, a thyroid, autoimmune thyroiditis, endemic goiter).

Ho'onui i ka kukuna

'O ka pae o kahi hormone e like me T4 (free) (ke kūlana ma'amau i nā wāhine a me nā kāne i hō'ike'ia ma luna) hiki ke ho'onui'ia me ka mea'awa'awa, TTG-kū'oko'a thyrotoxicosis, he nui. 'O ka ho'onui'ia o ke kukuna i'ike'ia e pili ana i ke kūlana o ka ma'i nephrotic, heparin therapy. 'O nā kumu e komo pū ana me ke choriocarcinoma, ka lawelawe'ana o kāuroxin ma ka papa o hypothyroidism, ke loli o ka postnatal i ka hana o ka wāone thyroid, a me ka'ino o ke ake. E hiki ke ho'onui'ia ke kuhi (free) me kahi ma'i o ke kū'ē i nā ho'ohāhā thyroid, ka hyperyroxinemia dysalbunemic genes, nā kūlana e ho'onāukiuki i ka emi'ana o ka thyroxin globulin.

'O kouroxine a me ka hāpai

Hone i nā'ōmole o ka lauroid wāwae i nā mea a pau i loko o ke kino. E like me ka mea i'ōlelo'ia ma luna, nā mana e ho'oponopono i ka hana hana kūpona, pili i ka hana a nā mea steroid. Hiki ke ho'ohui pū'ia nā pilikino o kou'ōlohelohe thyroid me ka pi'i a me ka emi'ana o kāna mau hana. 'O ka waiwai nui o nā hana'ino i nā hana a ke kino i ka manawa o ke hali'ana i ke keiki. I ka loli ana o ka iaea ooieoeiiaeuiiai moku'āina o ka thyroid gland e loli ai i ka holo ana o ka hāpai keiki, i kona ano, a me ka hope o ke kūlana o ke keiki. 'A'ohe o ka lawe'ana me nā ma'i o endocrine i'ōlelo'ia. 'O nā ma'i o kēia'ano, e like me ke'ano o ke kānāwai, alaka'i i ka uhaki'ia'ana o ka hana hānau, ka no'ono'o'ole. Loa pinepine diagnosed i hāpai keiki goiter (he mahuahua ma ka thyroid eiei? Ano) me ka euthyrosis ola, e like me autoimmune thyroiditis, e hoʻonāukiuki loli ma ka hormonal kāʻei kua. No ke kau'ana o ka manawa, ke'ano o ka loli o ke kūlana o ka'ōma'a.

Mana'o

No ka ho'ākāka pono'ana i nā hualoa'a o nā ho'okolohua'enehana i ka wā e hāpai ai, pono e mālama'ia kekahi mau helu. 'O ka wehewehe o ka mea nui T3 a me T4'a'ole hō'ike. Loa'a kēia ma ka mea i ka wā o ka hānau'ana, e ho'onui'ia kā lākou ho'onui'ana i ka manawa a me ka hapalua. Ke'ike'oe i ke kūlana o kāu thyxx, me ka ho'ohui i ka mana'o o ka TSH. Ua ho'onui'ia kouroxine ma kahi o 2% o nā wāhine hāpai. Ma ka hapa mua o ka manawa antenatal he emi ma'amau i ka TSH (kokoke i 20-30% o nā ma'i me ka singleton a me nā mea a pau me ka nui o nā hānau'ana). I ka ho'oma'ama'a'ana i kāu hua'ōlelo, ke nānā wale'ia'o T4 (free). Hiki ke ho'oha'aha'a'ia ka palena o kouroxin i pili'ole i nā hua hope. I kēia hihia,'o ka ho'onui'ana i ka TSH e mau i nā palena kūpono.