"Endoxane": aʻo no ka hoʻohana 'ana, maoli counterparts, ke Hookah

Uluwehi O "endoxane" pili i kekahi pūʻulu o Anati-ʻeho konohiki. Ke kaumaha ma muli o ka palapala o ke kalaʻana aku ka mea, hiki ke lawelawe hōʻike waha paha parenterally. He aha 'ano o ka lāʻau' hoonoho i, a ma ka laʻau heluna, Wehewehe i nā hāʻina wale kauka ma ke kumu o ka maoli ana o ka hoʻomanawanui ka kulana.

I ka haku mele 'ana a me ka waiwai o ka lāʻau

I ka papa kuhikuhiEʻeleu 'Oponopono o ka lāʻau "endoxane" kauoha no ka hoʻohana pili i ka cyclophosphamide. Hoʻokahi papa he 50 mg o ia. Ka lapaau pili ia i ka pae ana o antitumor ai 'a me ka mea he biconcave o na papa io me ke keʻokeʻo wahī, a me ka' ōlelo o ka mea hookahi hue. Like hou eiiiiiaiouʻeleu mea lāʻau lapaʻau huahana ec paʻapuna a me ka hydrogen posapahate, paʻakai karamellozu, glycerol, gelatin, lactose, ke kulina pia, macrogol, makanekiuma stearate, polysorbate, sucrose, talc, ka silica i a me ka titanium.

He aha ka ka pharmacology o ka waiʻona?

I ka papa kuhikuhiEʻeleu lāʻau waiwai, o cyclophosphamide, alkylating a he cytostatic hopena. Ma kona ano, ia mea kokoke i ka sinapi kinoea, naikokene i kona mea like.

Keʻano papa hana o ka hana o ka cyclophosphamide ma muli o ke kahua o crosslinks ma waena o DNA nā lātoma a me RNA, a kumuʻiʻo hoʻololi kemikala uhi kino.

Nā pharmacokinetics o ka lāʻau

I ka papa kuhikuhiEʻeleu 'Oponopono "endoxane" ka lāʻau i kokoke piha degere o ka absorbability mai ka gastrointestinal'āpana. Kona lehulehu i loko o ke koko ma hope o ku una, a intravenous hooponopono i ka ia. Cyclophosphamide pūnao ia lŘlŘ kuhikuhi ma ke akepaʻa, ma lalo o ka aoao o ka microsomal oxidaseʻano papa hana o ke kahua o ka hana alkylating metabolites. Kekahi o lakou e hoohuliia mai i loko o AEeOEXAaI ano, kekahi pae ua nee aku no ia i keena, ma ka enzymatic hana o phosphatases iho i loko o 'ona me ka cytotoxic waiwai.

Ke degere o ka paa ana o ka palapala ano o ka lāʻau a me ke koko nā polokina mea negligible a me ka mea 12-14%. Eia naʻe,ʻo ia anakahi o metabolites lākou, ua 60%.

cyclophosphamide hua mai ia eʻaʻa puʻuwai excretion ka hapanui i loko o ka palapala o metabolites. Ka hola 5-25% o ka lāʻau ua excreted i loko o kona palapala ano i loko o ka mimi a me ka bile.

Aiao T1 / 2 i loko o lākou, ai '7 hola no nā mākua a me 4 hola na keiki.

Ma ka mahele lāʻau, e lawe i ka laau?

Uluwehi O "endoxane" ma ka papa palapala ia hōʻike waha 'muaʻai a me ka hapalua o ka hora ma hope o kaʻaiʻana, ma hope o 2 hola.

Aie i ka mea i ka mea lāʻau lapaʻau huina hoonui me ia ma ka helu nui o chemotherapeutic regimens, ke koho pololei o ka aaieieno? A me ka laʻau heluna kauka manaoia pākahi.

"Endoxan" - papa - alakai ia kekahi ka laʻau heluna 1-3 mg / kg kino ke kaupaonaʻana no ka lā, a hiki e mai ka 50 a hiki i 200 mg cyclophosphamide no ka 24 hola. Ka lōʻihi like 'ole o ka hana, he 2-3 pule.

Inā ua lawe pu i ka lāʻau a me nā ai 'i i Anati-ʻeho ka waiwai, i ka dosage o na kumu a pau o Inc undergoes e hooponopono.

Hiki loaʻa e ka overdose?

Ke alo aku o kekahi mau 'antidote i loko o ka hoʻomākaukau "endoxane' kauoha no ka hoʻohana 'ia' i hookupaa iho la ia. I Ina o oi aku ka makemake mahele lāʻau e waiho ia no ka hoʻoponopono Inc like kūpono lapaʻau o infectious maʻi, withdrawal symptoms cardiotoxicity a me ka myelosuppression hoʻopau.

E like me ka lapaau ua hui me nā ai '?

Inā ka hoʻomanawanui i nā mea hoʻonāukiuki microsomal'okesaside ma ke akepaa, a laila, i ka hui lapaau me ka lāʻau "endoxan" aʻo Hōʻike loa hoʻololi kemikala o metabolites me ka alkylating haʻawina, ua hoʻemi hapa-ola o ka cyclophosphamide, a māhuahua kona ka hoʻokōʻana.

Kēia lāʻau inhibits cholinesterase hope, a metabolic alahele cocaine, mahuahua kona kaʻawahia, a maoli he ka ka hoʻokōʻana o ka suxamethonium.

Inā "endoxane" hoʻohana i ka huipūʻana me "Allopurinol" i loaʻa ua hoomahuahua ia kona hopena maikaʻi 'ole ma o ka iwi lolo.

Ma ka hihia o i ka wā hoʻokahi lapaʻau me ka cyclophosphamide, colchicine, probenecid, sulfinpyrazone kauka ana pololeiʻiʻo nō ia mahele lāʻau Anati-gout ai '. Keia ua pili me ka mahuahua pilikia o ka nephropathy i loko o ka ami palapala noi "endoxane" me ka uricosuric ai '.

Cyclophosphamide ho'ēmi i kā hoʻololi kemikala kumumea i loko o ke akepaa, he kuleana no ke koko a me ka clotting platelet? Iecaianoaaiiie, nae, oiai lapaʻau me anticoagulants emi hope ana o ka hope.

Hoʻomanawanui iki mai e lawe i ka lāʻau "endoxan" manual ia kekahi i kaʻai waho aʻeo ka grapefruit wai, no ka mea, loaʻa eiiiiiaiou e kue ana i ka ho'ā hope ka hoʻokōʻana, a me ka papa hana 'Oponopono o ka medicament.

I ka Makeke-lawelawe me ka cyclophosphamide "Doxorubicin" a me "daunorubicin" ua listen cardiotoxic hopena o kēia mau ai '.

Hui pu ana, a me nā immunosuppressants, e like me "Azathioprine" "Tacrolimus", "Chlorambucil", "SSC", "Merkapturin" hiki aku ai i ka hua i loko o ka hanana o ke kiʻekiʻe nā mea palahēhē a me kaʻeho type.

Ma ka hihia o ka hui ana "endoxane" a me ka "Lovastina" i loko o nā mea maʻi me ka naau transplantation e ia i ka pilikia o ka rhabdomyolysis a me kaʻaʻa puʻuwai ole i loko o ka huʻi palapala.

Inā lapaʻau me ka cyclophosphamide hui me ka mielosupressantami a me ka pāhawewe Inc, e mea hiki ke loaa ugneeniya papa iwi ka lolo.

I ka wā hoʻokahi? Eaia "endoxan" me kiʻekiʻe-mahele lāʻau cytarabine ma e hoomakaukau ai manipulations i ka iwi lolo transplantation maoli i ka mea hiki wale mai o ka ona cardiomyopathy.

Pehea i keia k ma reproductive kuleana pili i?

Uluwehi O "endoxane" ahonui e hoike hoao ia, hiki hoʻonāukiuki sterility i loko o nā mea maʻi o nā sexes, a i e irreversible.

Ma ka hapanui o na hihia, na wahine amenorrhea i, akā, menstrual regularity ana ola i loko o kekahi mau mahina ma hope o kanaka me ka cyclophosphamide. Inā Inc Ua lawe mai i loko o prepubertal na kaikamahine, deviations i loko o ka ulu ana o ka kiʻekiʻe 'īnea i hoike ana i ka malamaia. Menstruation ua maʻamau, i nalowale fertility.

Ma ka iapaau ana o ke kane lāʻau "endoxane" aʻo i ka 'ia i loko o kekahi mau hihia i hoike azoospermia paha oligospermia. Kēia mea aie i ka māhuahua? Iecaianoaaiiie o gonadotropins i ka uku o ka testosterone kala. ua i hoemiia libido pae a me ka potency i loko o nā kānaka. Inā lapaʻau me ka cyclophosphamide hua mai la i ka prepubertal keiki, ua hanaia maʻamau ka obazovanie kiʻekiʻe 'īnea i hoikeana. Eia naʻe, na hihia o ka azoospermia, oligospermia a me ka hana ana o gonadotropins i ua kaulana. Ua hiki no hoi i hoʻomaka ai testicular atrophy. Ua mea waiwai 'ana i kumumanaʻo i ka azoospermia mea reversible, eia nae o ka loaa ana o ka mana e hana ana i loko o ka makahiki kakaikahi ma hope o ka pauʻana o ka nohoʻana.

He aha nō nāʻaoʻao hopena o ka lāʻau?

Lawe ka lapaʻauʻia "endoxane 'kauoha no ka hoʻohana ua hookupaa iho la ia, ka mea hiki i kekahi kāna hana o ka hemopoietic'ōnaehana:

• Leukopenia, neutropenia - he pinepine.
• Emi, he pono ole i anaemia, a thrombocytopenia.

Ma hope o 1-2 pule, mai ka hoomaka ana o ka lapaau, i ka hoʻomanawanui i hōʻike mai i ka i kā mākou ka ho'ēmiʻana o nā leukocytes a me platelets i loko o ke koko. e hoihoi hou ia mau mea kiko'î i ka maʻamau i loko o 7-10 lā o ka hope o ke Inc.

Ma ka iapaau ana me ka cyclophosphamide hiki iʻaoʻao reactions o ka gastrointestinal'āpana.

• Nausea a me ka luaʻi.
• Anorekisya.
• Stomatitis.
• Pain i loko o ka abdominal māhele 'āina.
• Noho paewaewa.
• Jaundice.
• Hemorrhagic colitis.

Kākaʻikahi ka hoʻomaka ai akepaa dysfunction pili me ka loa haʻawina o nā'ūhū a me bilirubin pae ala. Muli o kona kulana he nui pūʻulu o nā mea maʻi i i anaemia aplastic , a loaa kiʻekiʻe-mahele lāʻau "endoxane" a hoʻohuiʻia ia me ka busulfan, wahi a endoflebit hepatic aa koko. O kŰia ke hana 1-3 pule ma hope o ka iwi lolo transplantation, a ua hoikeia mai ma kahi nihinihi hiki mahuahua ma ke kino nuipa a, ascites, hepatomegaly a me ka hyperbilirubinemia, hepatic encephalopathy.

Ma mua o ka lāʻau hiki i undesirable reactions i kaʻili.

• Reversible alopecia.
• Wikiwiki.
• Ke pigmentation o ka ili a me ka maiuu.

Ua hiki ke triggered no hoi ma o ka 'aʻe' ana i ka urinary'ōnaehana i loko o ka iapaau ana o ka lāʻau "endoxane". Na Ke Kumu, hōʻike manaʻo o nā kauka, a hoʻomanawanui iki mai i ka hōʻike kekahi mau Hawaii:

• Cystitis hui me ka fibrosis bladder (ai ole ia).
• Hemorrhagic urethritis.
• Necroticʻike manaʻo tubule a hiki i ka make.

I mimi, i ka hoʻomanawanui i ke 'akomi i ma ka epithelium o ka urinary bladder. Inā i ka palapala o ka hemorrhagic cystitis kaumaha, e lawe ana i ka lāʻau 'ana. Ka pono Kāohiʻana o keia ano o ka ka lapaʻauʻia "Mesna". Inā "endoxan" mahele lāʻau, a mahuahua nui, hiki hoʻomōhala hakuʻala dysfunction like nephropathy a me ka giperurekemii.

Inā ke hoʻomanawanui i ka nuiʻano o ka immunosuppression, alaila, i ka iapaau ana o ka cyclophosphamide i ike 'loa nā mea palahēhē.

I hiki ke kūkulu i ka kēiaʻaoʻao ole:

• Cardiotoxicity (kiʻekiʻe nā māhele), loa degere o ka naʻau ole.
• Pulmonary fibrosis, interstitial ano.
• Hoʻohuikau o spermatogenesis a me ka oogenesis, reversible a me ka irreversible sterility.
• Ka hooulu ana o nā haumāna malignant neoplasms e like me Ka maʻi 'aʻai o ka bladder, mieloproliferatsiya a me ka lymphoproliferation.
• Allergy like poʻe noʻonoʻoʻole, ka ohane, urticaria, i kekahi manawa ma ke ano o ka anaphylactic NaI.
• Ilihune eha ho'ōla.
• Lehalehu t flushing, sweating, headache.

Ke ola ana o ka meaʻaoʻao 'ole, mai ka lalau ana i ka lāʻau' e mau ke hoala mai i ka ninau e pili ana i ka hiki pomaikai e ku ei ka mea hiki ka pilikia no ka mea kēia mea hoʻomanawanui.

A maʻi i koi 'ia k ‰?

Papa "endoxan" e e hāʻawi ai i ka hoʻomanawanui ina mea i ka i kēia maʻi.

• Hodgkin ka maʻi.
• Mau myeloma.
• Umauma Ka maʻi 'aʻai.
• Lymphoblastic lymphoma i ka huʻi a me maʻi palapala.
• Ole-Hodgkin ka lymphoma type.
• Retinoblastoma.
• Neuroblastoma.
• Mycosis gribkovidnogo külana.

Ua Hōʻike ka acceptability o ka palapala noi i loko o ka luna 'anticancer Inc pili ana i ka lāʻau "endoxane" ke aʻoʻia. Ka Hookah ia kekahi mea loaʻa i loko o ka iapaau ana o cervical Ka maʻi 'aʻai, a bladder Ka maʻi' aʻai, akemāmā Ka maʻi 'aʻai, a prostate Ka maʻi' aʻai, sarcomas a me reticulosarcoma, maʻi Ewing a me Wilms.

Ka lāʻau cyclophosphamide-ma muli hiki ke hoʻohana i immunosuppressant e holumua ai autoimmune maʻi e like, psoriatic a me rheumatoid arthritis, haemolytic anaemia, collagen maʻi, nephrotic maʻi pale, e like me ke pale aku pakuiia auanei lakou rejection.

I ka wā o ka lāʻau ua contraindicated?

Ka medicament "endoxan" i ke kaumaha contraindications, me:

• Hāpai keiki, a lactation.
• Cystitis.
• Nā mea palahēhē ma kaʻeleu palapala.
• Kue o ka iwi lolo functioning hai palapala.
• Ke alo aku o ka hypersensitivity a hiki i ka hoʻokumu a me ka hou lāʻau 'ona.
• urinary ka mālama.

Special malama kauka i hoakaka ia i ka lāʻau i loko o nā maʻi o ka naau, a me ka hakuʻala akepaa, ke koʻikoʻi, gout, adrenalectomy, i ke alo o ka infiltration keʻano o ka hanaʻana i loko o ka iwi lolo, nefrourolitiaze.

I Kekahi Mau alakaʻi ma ka iapaau ana o

Ma 'ai, inu "endoxan" kumuhana i ka hooponopono ana i ke koko obligatory (neutrophils a me platelet helu) a me ka mimi (i ke alo o kaʻulaʻula koko aeee) o ka hoʻomanawanui.

ka mea, ua pono e hele lapaʻau "endoxane" 'o ia hoʻi i loko o kekahi mau hihia. Na Ke Kumu ma ka hoʻohana 'ana o nā huaale paipai e hana ai ma lalo o ke ana ma lalo nei:

• Hōʻike o ke kīnā nā hoailona cystitis.
• Ua hakumakuma i ka lehulehu o leukocytes a me platelets i ka pilikia nā loina.
• Hanana o ka maʻiʻaʻai (mahele lāʻau? Iaea mea hiki ia).

Inā "endoxane" ua hoʻohana 'ia i loko o nā māhele kiʻekiʻe, ka hoʻomanawanui ua hoakakaia ka lapaʻauʻia, "Meena" no ka Kāohiʻana o ka hemorrhagic cystitis type.

Ma ka iapaau ana me keia k e mea iki aku oukou inu waiʻona, a me ka hoʻohana 'ike loea ano o ka contraception.

Inā ka hoʻomanawanui ua ia "endoxan" no 10 lā ma hope oʻoki kino me ka mau anesthesia, ka anesthesiologist ua lohe e pili ana i keia.

Ma hope o adrenalectomy hana i kekahi mahele lāʻau hoʻoponopono "endoxane" a me ka 'ē aʻe ai' corticosteroids.

lāʻau analogues

Inā he mea kaumaha contraindications a me ka pilikia, laila, i kaumaha aku ai, e haawi aku i ka lawe ana i ka lapaau "endoxane" ke aʻoʻia. Analogs hiki ke hoakaka ia e ke kauka me ka makemake kupono. I waena o lākou:

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "Cyclophosphamide -Lens".
• "Endoxane - Astana".

Kēia 'ike He He Nohie hoʻokolohua o na kuhikuhi a hiki i ka lāʻau "endoxane". Ke kumu o keia k ua i wale ma ka hele kauka.