Ka lāʻau "Baraklyud": aʻo no ka hoʻohana 'ana, ano, haku mele' ana a me ka hōʻike manaʻo

"Baraklyud" pili i Anati-retroviral ai ', kekahi hapa o ka pae ana o nucleoside analogues. Hoakaka ia no ka iapaau ana o ka maʻi HBV-maʻiʻaʻai. Kaʻeleu 'Oponopono o ka lāʻau entecavir koke suppresses mea hoʻomaʻi replication o hepatitis.

Ua pono koiia e? Anoee annotation mua e lawe i ka waiʻona. E like me hōʻike ma na olelo ao no ka hana? "Baraklyud" (Baraclud) - i ka lāʻau a ua manao ia e hoʻomaka i ka backflow o fibrotic keʻano o ka hanaʻana i loko o nā mea maʻi i ake cirrhosis.

i ka lāʻau

Ka lāʻau 'Ua loaʻa i loko o nā laʻau heluna koho - 0.5 a me 1 mg entecavirʻeleu ke keʻena visually pu ole, ma ka kalameaʻai ano (keʻokeʻo paha a pink, niioaaonoaaiii).

Ka hoʻomākaukau nō hoʻi ka loaʻa o:

• polysorbate;
• makanekiuma stearate;
• lactose monohydrate;
• Valium;
• povidone;
• colorant Opadry.

Pharmacological 'ole

Kaʻeleu 'Oponopono ka entecavir a mea he mea like no ka nucleoside guanosine, ua hai e wae hanana hulina i ka hepatitis B.

Entecavir ua phosphorylated i kaʻeleu triphosphate me ka hapa-ola o ma kahi o 15 hora, i ka intracellular maʻiʻo o i ua pili i ka lehulehu o entecavir waho keena. A pau keia ua i malama appreciable hoʻomāhuahua oʻeleu waiwai i loko o ke kino. Medicine "Baraklyud" kauoha no ka hoʻohana i ka 'kona kiʻekiʻe ka hoʻokōʻana, suppresses ka ha awina o ka mea hoʻomaʻi polymerase, impacting ka poʻe ma luna o ekolu kumumea:

• hoʻololi kemikala o ka maikaʻi ili aku ai o DNA HBV;
• e hoole Ekolu a o ka hopena maikaʻi ka pae pregenomic mRNA;
• HBV priming'ūhū.

Triphosphate mea,ʻaʻole he retarders ikaika nā'ūhū ke kelepona hele DNA, e like me ka paa ka maʻiʻo oʻaʻohe ole ma mitochondrial DNA hoʻololi kemikala.

kanawai o ka lāʻau

Kaʻeleu lāʻau waiwai mea hiki ia o ka pōkole manawa e ke kemu, mai ka digestive'ōnaehana, a ma hope o ka lawe i ka papa ea i ka i kā mākou o kona Contents ma 30-90 minuke.

Puaʻa heʻa ala mahuahua ana i loko o Cmax a AUC indices ia lŘlŘ ma mahope ana o 0.1-1 mg o medicament "Baraklyud". Na Ke Kumu no ka hoʻohana kamailio e pili ana i ka hoʻokō 'i ke koena i loko o ka 6-10-la lā o ka hookahi mahele lāʻau o ka lāʻau no ka lā. E ho ohana i ka momomaʻai me ka nui loa complicates entecavir omo kaʻina, unuhi nā loina Cmax a me AUC ma ka 45% a me ka 20% niioaaonoaaiii.

Ka lāʻau 'Ua hoʻomaka koke ke kemu i loko o ka'aʻaʻa, a ma ka 13% nakinakiia i ka wai koko nā polokina. Kaʻeleu lāʻau ke keʻena mea i pili i ka substrates,'ūhū nā mea kūpale a me inducers o P450 kahua. He hiki ke loaa ma ke kino a me ka auoiaea ma kaʻaʻa puʻuwai'ōnaehana ma glomerular kānana, a omo hookuuia.

nāʻikepili

Medicament "Baraklyud" paipai, e lawe ma luna 'lapaʻau o hepatitis B:

• Me ka papa symptoms o ka mea hoʻomaʻi replication a me ka mea ulu o ka degere o ka ha awina o transaminases i loko o ka lāʻau lapaʻau, i loko o ke alo o histological hoike ana mai o ka hoʻomauʻana li nui o ke akepaʻa.
• Unrecovered ake lesions.

Nui kokua o ke akepaʻa maʻi symptoms ana ma hope o ka lāʻau 'aaieieno? "Baraklyud". O na papa io manual ia kekahi hoʻomanawanui iki mai me ka maʻi hepatitis B, ake maʻi huikau ma ka penei:

• ke aupuni 'decompensated;
• pathological ake ano i loko o ka ukuʻanuʻu ka wā hoʻouka kekahi mea hoʻomaʻi replication diagnosed hoikeana o ke akepaa fibrosis me ka mahuahua AST a me ka Alt.

Contraindications

Ka lāʻau "Baraklyud" i ka kēia contraindications:

• mahuahua susceptibility e entecavir a me nā waiwai i komo i loko o ka lāʻau haku mele 'ana;
• hereditary lactose intolerance, monakō koko-galactose malabsorption, deficiency a kaawale i loko o ke kino o ka'ūhū lactase ;
• kona mau makahiki i emi o ka makahiki 18.

People me ka hakuʻala ole pono e lawe i ka lāʻau ma kuhikuhi, a ma lalo o ia a eia 'inikua hooponopono.

? Eaia "Baraklyuda" i hāpai keiki ua i paipai ma Inc Pono e paʻa breastfeeding.

ʻaoʻao waiwai

Aia paha e kekahiʻano o kāna hana o ka digestive'ōnaehana i lāʻau lapaʻau "Baraklyud". Na Ke Kumu no ka hoʻohana i maopopo i ho'ākāka 'iaʻaoʻao ole:

• digestive kāna hana;
• diarrhea;
• nausea a me ka luaʻi;
• dyspepsia.

E hiki no hoi ka mahina headaches, Kanikani'āʻula a drowsiness, lilo o ka ikaika loa ka makemake, a me ka allergic reactions.

Ana ka lapaʻauʻia me ka pau pākōlea hope paha ma ka hoʻohui pū 'ia me nā antiretroviral ai' hiki i loa hepatomegaly me steatosis, a e alakai i ka hoʻomanawanui i ka make.

Ma nā mea maʻi me ka decompensated manao laktatsiadoz lesions kānāwai akepaa, a ua wehewehe aku ma:

• mau Muscle nawaliwali;
• kokololio hanu a me ka helehelena o ka pokole o ka hanu;
• nausea;
• nui ka ho'ēmiʻana o ke kino ke kaupaonaʻana;
• ʻeha i loko o ka peritoneum, epigastric.

Nō hoʻi, i ka lāʻau hiki i kekahi mau reactions a me ke kino.

• hoonuiia holo 'awelika o hepatic transaminases;
• ili lapuwale ia;
• anaphylactoid naoh.

ʻO nā mea maʻi no hoi e loaa ana decompensated ake maʻi, ma ka hou, e like reactions i hoike mai ai ia meaola:

• ʻaʻa puʻuwai 'ole (ma ka pohihihi keia hihia);
• mahuahua bilirubin maʻiʻo i loko o ke koko;
• . Ua hakumakuma o ka platelet helu i 50 tausani / mm o ³ a emi;
• ka ho'ēmiʻana o bicarbonate i loko o ke koko;
• mahuahua ana o ka Alt;
• oi aku mamua o ekolu-pa mahuahua ana i loko o ka ha awina o ka lipase;
• hoemiia pae o ka albumin.

Medicament "Baraklyud": laʻau heluna a me ka hooponopono

Ka lāʻau 'E e ia ma luna o ka ipu opu, i ka manawa au mai ka hopeʻai ma mua o ke dosing e e oi aku, elua no hora.

I ka compensated ake poino paipai? Eaia "Baraklyuda" 0.5 mg kela la i keia. Ma nä ia'ku e lamivudine laʻau heluna E e pāpālua.

Nā mea maʻi i ake lesions unrepaired hoakaka ia i kela laʻai ana o 1 mg. No ka mea kūpuna a me nā mea maʻi me kaʻaʻa puʻuwai insufficiency, i ka mahele lāʻau e e like ke kaumaha ma muli o ka nui o ka CK (creatinine lehulehu) i loko o ke koko.

overdose

Information ma na hihia o ka lāʻau overdose mea,ʻaʻole lawa.

Nāʻaʻa, a i clinically ho'āʻo, loaa i kela la i keia laʻau heluna o 20 mg no ka pule mau mea i haawi mai i ka hookahi kiekie ae mahele lāʻau - 40 mg lāʻau "Baraklyud". Na Ke Kumu no ka ho ohana i hākālia nō ia hopena maikaʻi 'ole i' akomi i.

Paipai posindromnoe lapaau ma lalo o ka hooponopono ana o lapaʻau hoike ana.

AaOIeIOUIeXAOAaIN me nā ai '

Aie i ka mea i ka hana ke keʻena entecavir ua excreted kuhikuhi ma kaʻaʻa puʻuwai'ōnaehana, luna 'Inc ma ka hoʻohui pū' ia me ka 'ē ai' ana i kauoha oleʻauhau'ēʻaʻe 'ole ma hakuʻala hana, a he aha ka mea omo secretion, e' ai pono i ka hua i loko o ke kino o ka entecavir a me na hana waiwai o ai '.

AaOIeIOUIeXAOAaIN "Baraklyuda" me ka adenovirom, tenofovir, lamivudine i i kakauia.

precautionary ana

Ae o ka lāʻau e hoomanawanui i hoʻopale ai i lamivudine hiki aku ai i ka pilikia o ka ulu e kū'ē'ē mai.

Nō hoʻi, he mea hoike o ka hanana o exacerbations o hepatitis B ma hope o discontinuation o ka lāʻau "Baraklyud". Na Ke Kumu no ka hoʻohana iienuaaaony i ke kokua ana o exacerbations me nā Inc.

Cautions

? Eaia "Baraklyuda" i loko o ka? Aieao o monotherapy, a hui lapaʻau me nā antiretroviral konohiki, hiki i lactic acidosis, hepatomegaly me ka steatosis. Ma keia hihia, he mea he pilikia o ka make.

At kamepiula e hoomanawanui i loaʻa i ke kēia waeʻano.

• e loaa ana mai ka hepatomegaly;
• ia e hana me ka hoʻohana 'ana o nucleoside analogues;
• me overweight;
• wahine nā mea maʻi.

Na Ke Kumu no ka hoʻohana ana i ka lāʻau "Baraklyud" memo i ka manawa kūpono o ke kahua o ka hoʻopale mea hoʻomaʻi ke kanana nei. ʻeleu 'Oponopono entecavir lāʻau ua ole e waiho no ka iapaau ana o kanaka immunodeficiency mea hoʻomaʻi no ka mea, o ka ka hoʻokōʻana i loko o kēia ala e hiki aku i ole i? Anoee i piha.

Ma ka iapaau ana o nā mea maʻi me ka pathology o kaʻaʻa puʻuwai nenoaiu, Ua pono, e hooponopono i ka mahele lāʻau.

Ke ola a me ka laulā o ka hoʻohana "Baraklyuda" no ka iapaau ana o nā mea maʻi ma hope o akepaʻa transplantation ka mea,ʻaʻole iʻikeʻia, a koi kūikawā kaʻaeʻana ana.

Waho pūnaewele kumu a me ka waiwai e lilo aku

Pūnaewele a me ka halihali ana o pellets e halihaliia oia iwaho i loko o ke ana wela huahelu 15-25 ° C. Ka la hoomalolo aole ia e pono no ka hoʻohana no ka makahiki elua, mai ka lā o ka hana.

Ka lāʻau 'ua komo i loko o ka pūʻulu kaawale o ka nui laau lapaau, a no kekahi mau waeʻano o ka makaainana i noa hānau o ka lāʻau "Baraklyud". Na Ke Kumu no ka hoʻohana hoʻopioʻana i kēia mea.

Price loa ma Moscow keʻena kūʻai lāʻau lapaʻau hoomaka mai ka 12 tausani. Rubles.

Views o nā mea maʻi

Ua Hōʻike ke kiʻekiʻe hopenaʻoi loa o ka lāʻau "Baraklyud" manual. Price, hōʻike manaʻo o ka i hoike mai ia ia ua kemokalaka ma ka e like me analogues o ka lāʻau, loli aʻe ma waena o 12-17 tausani no AEeAaOA, ma a 30 pellets. Kēia hana o ka lāʻau i ka loa mahalo, a me ka koi i waena o nā mea maʻi no ka iapaau ana o ka hepatitis B.

Ma ka hopena maikaʻi manaʻoʻano nui haawiia proitvopokazaniya a me kaʻaoʻao 'ole o ka lāʻau', e like me Kanikani'āʻula, a me ka nausea.