"Pradaksa" - analogues. "Warfarin", "Ksarelto": hōʻike manaʻo, nā kumukūʻai o

Iwaena o antithrombotic konohiki hoʻohana e wehe i ka thromboembolism i loko o na aa koko ma hope oʻoki kino, o ka loa efficient hōʻike makaukau "Pradaksa". Kona analogues i nui nāʻikepili no ka hana, a ma o ka 'ole i okoa hana nā mea hoʻohui. Anticoagulants i loaʻa i loko o paa laʻau heluna ano me kekahi mau dosages.

Description "Pradaksa" lāʻau

Hookah antithrombotic a me ka anticoagulant ka lapaʻauʻia "Pradaksa" ka poe "Boehringer Ingelheim Pharma GmbH & Co. KG. KG ". Available ano ma paakiki capsules, i pihaʻi me loko uuku yellow pellets. Kaʻeleu waiwai dabigatran etexilate noʻonoʻo AEeOEXAaI palapala, i ka helu o ka mea e hoʻoholo i ka laʻau heluna o ka lapaʻauʻia. Ua hiki e 75 mg, 110 mg a me 150 mg.

He aha lāʻau "Pradaksa" ua hoʻohana 'ia

I ka papa kuhikuhiE manao o capsules ua pili i ka Kāohiʻana o venous thromboembolism ma hope oʻoki kino, mālama i loko o ka musculoskeletal nenoaiu.

Pehea ka hoʻopololei "Pradaksa"

Ua Ua pili me ka suppression o ka thrombin ha awinaʻano papa hana o ka hana o ka ai ' "Pradaksa". Analogs ho'āʻo iki waiwai. I he uuku lātoma, dabigatran etexilateʻaʻohe pharmacological hana.

Wale komo i ke kanaka kino, ua Wāwahi ka waiwai ma hope o hydrolysis i ka noa dabigatran e hana reversible nā moʻopuna hoʻok & inhibitor o thrombin'ūhū. Ke kūlana o ka thrombin ua paa i ka fibrin, thrombin, hoemi aeea aggregation o platelet, kena ae la ma ka thrombin hope.

mau hana

Ua lāʻau "Pradaksa" counterparts. Akā, i loko o kona haku mele 'ana, ka mea e mai i pihaʻi dabigatran etexilate, ka mea, ua auou caiaiai me nā anticoagulant konohiki. Ke'ī mai, ka hana 'Oponopono likeʻano "Warfarin" ka warfarin, ma ka medicament "Ksarelto" be rivaroxaban. Synonyms hoʻomākaukau "Pradaksa" noa i ka ' "Marcumar" a me ka "Fenilin" nā phenprocoumon a me ka phenindione pakahi.

Description "Warfarin" lāʻau

Mākou i mua i makemake ai, a i ka lāʻau "Pradaksa" counterparts. E iā mākou e noʻonoʻo i oi au mamuli kekahi o ia mau mea.

Ka medicament "Warfarin" ua hua mai i loko o ka palapala o ka papa me ka laʻau heluna o kaʻeleu 'Oponopono, 2,5 mg. Ke Hookah o ka lāʻau o ka Lūkini poe "Kanonfarma? Iecaianoaaiiuo."

Aia nō 'ē aʻe laʻau heluna (1 mg, 2 mg, 3 mg a me 5 mg) haole ma muli lāʻau warfarin. Ke kinona, waihoʻoluʻu a me ka nui o na papa mea okoa ma kekahiʻaoʻao o ke pili keia mahele lāʻau i loko o mg.

No ka mea i ka lāʻau e hoʻohana 'ia

? Eaia "Warfarin" Ua hiki ia:

• thrombosis o ka venous'ōnaehana paha predisposition;
• no ka mea prophylactic lapaau o thrombosis a me ka thromboembolism;
• ma ka huʻi venous thrombosis i a me ka embolism i loko o ka akemāmā'aʻaʻa;
• ma postoperative thrombosis;
• huʻi myocardial naau Muscle;
• iʻoki kino a me ka thrombolytic Inc o thrombosis;
• me ka transient ischemic ho'āhewa wale;
• no ka hooloihi ae i lapaʻau o recurrent venous thrombosis;
• ma ka prosthetic kiwikā i loko o ka naʻau.

Pehea ka Agena

I Kekahi Mau oihana mua o ka mea "warfarin" ho'ēmi i ke koko clotting kumumea inhibit ka? Iecaianoaaiiie o (X, IX, VII, II), wikamina K-e kaukaʻi koko a me ka pono coagulation. Hepatic Anticoagulant nā polokina C a me S i synthesized i ka uuku loa ma lalo o ka aoao o ka lāʻau. A pau keia ho'ēmi i kā i ke kahua o ke koko clots e alakai ai i ke kahua o ke koko clots.

E hoʻopau venous thrombosis kauka i hoakaka ia hana maikaʻiʻole me kaʻauhau'ēʻaʻe anticoagulants. Kēia 'Aʻole i hou-ulu thrombosis, a hiki i complications.

I ka ho omaulia ana o ka mahele lāʻau o ka warfarin ma kekahi mau kumu INR

Ka hoʻokohu ' "Warfarin" lāʻau hiki ma hope piha ninaninau, a ma ia e hōʻike ana i nā contraindications. Ka Ikepili no ka hou lapaau wae i ka makemake nui o ka medicament "Warfarin". Ka mahele lāʻau no ka lā e ole oi 5 mg o ka papa kuhikuhi hana waiwai. Me ka lawa pākōlea hopena o ka iapaau ana lawe mai e hooponopono. ? Aeiiaiaiaaia e hoʻopaʻa i ka loaa mahele lāʻau, INR pae a me ka ona i kupu mai no ka Ikepili o ka Inc.

Ma lalo o ka INR (hoʻonohonoho 'normalized lākiō) imply maʻamau no ka hoomaopopo ana i ka ha awina o clotting koko hehee wale. koko clotting kumumea ho ololi i ka waiwai o ke anakahi. He nui ke kanaka hoʻoponopono i ka INR ka wā e loaa ana "warfarin" rationing i mea inversely hapaʻauhau i ke koko clotting. Penei, ma kiʻekiʻe normalized hiʻohiʻona 'aʻole hoʻi clotting a maoli he hypocoagulation.

I ka wā e e ua hoʻonānā kekahi mau Hawaii i loko o kekahi INR.

1. No ke ola i ke meaola, kona kūmau mea e pili ana 1.0 (a deviates iki - mai 0,85 i 1.25).
2. Maʻi atrial fibrillation ka wā e loaa ana "Warfarin" pellets pono e ukali ma kekahi normalized lākiō o ka 2.0 hiki i 3.0 huahelu.
3. Mechanical kiwikā prosthesis wehewehe aku ma ka INR o 2.0 e 3.0, he ÿano prosthetic mitral kiwikā mai 2,5 i 3.5.
4. Ma ka iapaau ana o thromboembolism i loko o ka pulmonary artery a me kekahi mau naau mā pono he nui Index o 2.0 e 3.0.
5. E pale aku thrombosis i loko o ka hohonu aa koko ma hope oʻoki kino, a no ka hana ana i venous thrombosis, hoopili i nā loina o ka 2.0-3.0.

Ka lāʻau "Warfarin" e halihaliia oia iwaho me ka akahele ka mālamaʻana o ka INR inideka a me ka ikaika 'inikua hooponopono, e e hiki, e hoʻomaʻa i ka laʻau heluna. Noaaeeecaoee normalized hiʻohiʻona a me ka wae ana o ka koi dala o ka medicament ua lawe mai no ma kahi o kekahi hebedoma, a lailaʻo kēlā kanaka 4 pule keia nui, kulana kupono.

E hele mai, mai ke kanawai o ka palapala noi o "Warfarin" o ka lāʻau, pehea e lawe mua i ka holoi ia, a ina paha o ka hui malu pu ana o ka ai, e pono e ike. Papa inu palua i ka lā,ʻaʻole hoʻohuiʻia me ka hoopau ana o ka ai. Ka mea, holoi iho la me ka wai, a lawe i na ia manawa. Eia hou kekahi, haawi o kālailai ma ka INR e ia i loko o ka Ia hora no, a me ka ka mau keʻena hoʻokolohua. A lohe o nā māhele skipping pono, e lawe mai i ka kela hapa o ka? Eaia manawa.

I holo 'awelika emi o 2.0 INR ua noʻonoʻo koko mānoanoa o ia mea, i ka lāʻau mea ineffective, nolaila, ia mea pono e hoʻohana i ka oi aku laʻau heluna "warfarin".

Ma hua'ōlelo o ka oi ma mua o 3.0 mea INR ua manaoia wai koko, kahe ana ke koko kānāwai, no laila hoi e pono e pili ma ka liʻiliʻi loa kiʻekiʻe laʻau heluna o ka lāʻau.

Ke kumukuai o ka lapaau "Warfarin"

I e like me ka German lāʻau "Pradaksa" kona Lūkini like paha o ka "Warfarin", ke kumukuai o ka i mea mai ka 80 rubles no pack, ia mea nui ho'ēmi a oi ho'āmana.

Description "Ksarelto" lāʻau

At medicament "Pradaksa" analogs paha e me anticoagulant waiwai, he pololei ole. lāʻau "Ksarelto" pili ia ia. Ua hua mai ia i loko o ka palapala o ka puni Auana lole komoʻuʻuku nona na papa i loko o ka German huakai "Bayer".

Ka haku mele 'ana i rivaroxaban ma micronized palapala. Papa "Ksarelto" i loko o ka hahai dosages: 2,5 mg, 10 mg, 15 mg a me 20 mg.

ʻano papa hana o ka hana

Rivaroxaban haawiia i like loa e wae pololei ololi Xa nā mea kūpale i loaʻa kiʻekiʻe bioavailability malamaia ma hope o ku una hooponopono.

Ke coagulation cascade ua hana ma ka ho'ā hope o ka ololi X, a, no i na, a mawaho coagulation alahele ua hoohuliia i loko o ololi Xa. Kēia ke keʻena ua komo i loko o ke kahua o ka prothrombinase hui, mai ka hana mai o i ka prothrombin ua hoohuliia i ka thrombin. Kēia mau keʻano o ka hanaʻana i hana i ka fibrin clot, a me ka haʻalele no platelets. Aia mea he "nahae" ma ka i no i ka ololi Xa lātoma e synthesized i kekahi tausani o kēia mau keena koko.

E ho ohana e wae nā mea kūpale e ho'ēmi i hana activator ia lŘlŘ pau ana "thrombin Naita me". Hana rivaroxaban kauoha e hoʻololi i nā hualoaʻa o ka ho'ākāka 'ia a mau keʻena hoʻokolohua Ka Ikepili ma aayoaeuiinoe i ka moku'āina o ka coagulation nenoaiu. Ololi Xa ha awina loli aʻe ke kaumaha ma muli o ka inhibitor mahele lāʻau, a lawelawe 'ana me ka lāʻau "Ksarelto" (15 mg o ka papa' ole 'ē aʻe laʻau heluna ia).

I ua malamaia lakou nei, me keia k

Ka manuale ho'ākāka i ka hoʻohana 'ana o kekahi medicament no ka Kāohiʻana o ka make ma hope o mea'ōnaehana mānowai koko mai pili me ka myocardial naʻau Muscle a me ka huʻi coronary maʻi pale. Medicine "Ksarelto" maikaʻi pūʻulu lākiō i loaa no ka mana i hoʻohui pū Inc i loko o ka huipūʻana me ka aspirin a aspirin a me ka thienopyridine.

Pehea e lawe okoa nā māhele o ka lāʻau

Ka lāʻau 'Ua manao ia no na hana. Maloko o na papa a pau nā māhele ia i ka ai.

I mea e hoʻopau huʻi coronary maʻi pale i ka manao, e lawe i kekahi papa o 2,5 mg palua i ka lā. Together me ka makaukau "Ksarelto" (lākiō i hōʻike i ka laulā o ka hoʻohana 'ia o ka hui malu pu ana o ia mea) hiki ke lawelawe acetylsalicylicʻakika i loko o ka kela la i keia mahele lāʻau o ka mai 75 a hiki i 100 mg, a me ka hui pu ana, o ka aspirin a me ka clopidogrel i loko o ka nui o ka 75 mg no ka lā. Kēia Inc Pono ikaika 'inikua hooponopono no ka ana o ke kaulike, a ua offset i kekahiʻaoʻao hiki i ischemic paha kahe ana ke koko pilikia. Lālau aʻela ia i ka lāʻau lōʻihi, a lawe ma kahi o hoʻokahi makahiki, i loko o kekahi hoʻomanawanui iki mai i ka mau makahiki.

Nā papa ma ka laʻau heluna o 10 mg rivaroxaban lawe i kekahi manawa i ka lā. Ka mua inu ma hope o 6-9 hola o ka kahuaʻoki kino me ka hoʻokō hemostasis. Ka lōʻihi like 'ole o ka hana me ka nānā' ana i ia i ka nui o ka lāʻau no kēlā me kēia hoomanawanui pākahi, ke kaumaha ma muli o ka pilikia o venous thromboembolism, ka manaʻo pohihihi a me ka 'ano o ka hana.

A hiki i ke kau lāʻau hooponopono "Ksarelto" Hip hope (10 mg papa) mau mai i ka 5 pule, i kukuli iho arthroplasty ka mea, ua laweʻia 14 lā.

Inā ka hoʻomanawanui ua poina e inu i kekahi mahele lāʻau o ka rivaroxaban, ia e ke koke hoʻopau, a me ka ia la ae, e hoʻomau i ka iapaau ana, 1 papa.

Kiekie dosages o 15 mg a 20 mg kekahi e lawe ma luna o ka nele'ōpū.

I mea e pale aku i ka moku'āina o ka hahauʻana a me ka systemic embolism ano me ka 'ole-valvular atrial fibrillation maoli atrial naʻau ka hoʻohana' ana i kekahi papa mahele lāʻau o 20 mg koke i ka lā.

I kaʻaʻa puʻuwai ole, i ka wa o ka uku o ka creatinine hoʻopau hapa-ola o ka emi o 30 ml no 1 minuke, ka hoʻohana 'ana i ka mahele lāʻau o 15 mg 1 manawa no ka lā.

Ka lōʻihi like 'ole o ka lapaau hilinaʻi nui ma luna o ke alo o ka make māinoino o ka hahauʻana a me ka thromboembolism moku'āina kahua hoʻonohonohoʻana.

ʻO kā mākou aho i kela la laʻau heluna e ole e oi aku mamua o 20 mg rivaroxaban.

Thrombosis, hohonu aa koko me ka hoohuoi ana, no ka mea Kāohiʻana o recurrence o ka maʻi a me ka thromboembolic ka heluna i ka pulmonary artery, ka hoʻohana 'ana i ka loiloi mua mahele lāʻau o ka 15 mg palua ia i ka lā i loko o ka mea mua ekolu pule. A laila neʻe maila i ka papa o ka 20 mg rivaroxaban kekahi manawa i ka lā no ka lōʻihi-makahiki lapaau a me ka Kāohiʻana o ka hou-thrombosis a recurrent pulmonary embolism.

Ia mea i manawa e hiki ai i nā mea maʻi e ale i ka a pau papa, o ka oi aku ka nui nui, a laila ka mea, ua 'ae' ia wili a hoʻohuihui me ka maemae ka wai a me ke kinowai ai mua hokii. Koke ma hope o ka lawe ana i ka lāʻau 'o ka hoʻomanawanui eʻai.

Ua mea i hiki ke hoʻolauna i ka paopao huaale ma gavage, i ke kulana o ka i loko o ka digestive'ōnaehana ua papa hoʻolaukahi ma ka mua me kou kauka. Terms ana pepe iho la ka papa ma keia aoao ninoieo i hoʻohuihui i ka lāʻau a me ka uuku nui o ka wai, a mahope i ka hooponopono. Hope i ua hoopihaia me ka wahi loli e wehe lāʻau residues mai kaʻimi. Ma hope o ka lapaʻauʻia pono, e lawe mai i ka enteral meaʻaiʻai ana.

Ke kumukuai o ka lāʻau "Ksarelto"

Kēia mea kökua ka pili ana i laweia mai ai 'me ka kiʻekiʻe kāki. No ka laʻana, ka lāʻau "Ksarelto" kumukuai o ka mea uuku mahele lāʻau e ia i loko o 56 pellets o ma kahi o 950 rubles. He nui oi pipiʻi ma mua o kona Lūkini mea like - ka lapaʻauʻia "Warfarin". I ka lapaau "Ksarelto" kumukuai, piʻi pū ke kaumaha ma muli o ka hoomahuahua i ka laʻau heluna. Penei, o ka waiwai 14 o na papa io o ka 15 mg rivaroxaban e ia ma kahi o 850 rubles, oiai ka hāʻawe (28 na apana o ka papa) me ka lani kiekie loa mahele lāʻau (20 mg poʻo kumu a meaʻeleu 'Oponopono) i, e uku mai ka 1450 rubles.