Kēia pohihihi aniani maʻi

Ke uie kekahi hapanui hewahewa o kanaka, kamailio e pili ana i ka naau, i ka lima a hiki i kaʻaoʻao hema o ka pahu. Naʻe, i ka 1643 o ka Italia surgeon Marco Severino ho'ākāka 'ia ma ka hihia mua ma ka moolelo o ka naau i ka akau, a ma hope i ho'ākāka' ia ma ka mua manawa i hou 50 makahiki ka piha transposition o na nā loko, i ike ia e like me ka aniani maʻi. Ma keia maʻi, i ka wahi o ka mea na nā loko o ke aniani kiʻi o maʻamau. No laila, i ka naau mea ma ka akau, ka mea no hoi maka i ke kihi o ka pono, o ka pono, a me ka opu, akā, me ka laau awaawa, a me ka bladder akepaa, ma ka mea ku ole, a hiki i ka hema. Liʻiliʻi, ke koko a me ka lymph moku, nä olonä i kekahi hoonohonoho i loko o ke aniani kiʻi. E honi ai i ke aniani maʻi pale, a seemingly symmetrical malamalama: i ka pono, he 2 lobes, a me ka hema - 3.

O ka hana ana, hoihoi i loko o kēia anatomical anomaly, hoomaka ae la kanaka e nana i kona mea, lalau mai. Ma ka Middle Ages aniani maʻi wahi like hana malu a diabolo a me ka makana akua. Ua Ua wale nui hope, ua loaʻa nä känaka 'epekema he wehewehe no keia pohihihi kŰia , a nakinaki ia ia me iniiaiie ciliary dyskinesia a me ka maʻi pale Kartagener. I mau, ke aniani maʻi pale - he genetically determenirovannoe maʻi pili me kaʻole haʻawina o ciliated epithelium, kena ae la ia e kekahi congenital kina morphology. Ma keia pathology ia lŘlŘ mutations i loko o 12ʻokoʻa nā'ōewe i encode ka hoʻololi kemikala o nā polokina koi 'ia no ka kūkulu a me ka ciliary kuleana pili i pololei. E like me ka hopena, nā mea maʻi i kāna hana naehana kāna hana like pilikia hookuuia o mucus mai ka naehana'āpana, a me na kanaka (kākaʻikahi wahine) i pinepine infertility.

Ma embryonic kūpono 'ana o ke fetus o ka neʻeʻana o ka cilia Ho'ākāka' ka iho (axis) e pili ana i ka uku pila nā loko, akā, no ka mea, i loko o ka hopena, ma ka 'aʻe ana i nā mana o cilia ana tranpozitsii. Like loa'ē aʻe aaiaoe abnormalities, maʻi ua wehewehe aku ma ke aniani autosomal recessive pololei o ka noho ana, akā, no ka mea, ka alapine (frequency) o loa haʻahaʻa. Wale nō ma waena o 1 i ka 10,000 a hiki i 1 i ka 60,000 kānaka.

I kekahi manawa, i pololei ai paʻakikī wahi, i hiki, he mea kāpili transposition o na nā loko: ka mea, aniani, akā nō haʻalele i ka naʻau ua. I ka 95% o ka hoopii, keia morphology nā mea maʻi e ae likeʻole congenital naʻau mā. Like no ka mea 'ē aʻe hihia, ke aniani maʻi pale, ka mea, uaʻaneʻane ole scientifically ai ia ma luna o ke ola, ka pono a me ka lōʻihi o ke ola. Hiki wale kekahi discomfort mai o ka mea i kanaka, ua nui ka ike ole aku o keia ka hiʻona, akā, no ka mea, i loko o ka hanana o ke ola pilikia kauka ka mea, he nui ma mua maka pilikia a me kaʻike, o ka maʻi.

Naʻe, i ka papa kiʻekiʻe o? Acaeoey o ke lapaau i 'ae' lapaau e diagnose ole wale transposition o nā loko mai o kanaka, akā, no hoi e hana i kekahi aaiaoe Ka Ikepili e kuhikuhi mutations i loko o ka pale umauma hoʻokahi nā'ōewe. Akā, i ka papa kuhikuhiE pilikia i ke alo kanaka me kaʻike, o "aniani maʻi" - He hui, transplantation. Aie i ka rarity o ka maʻi, huli kekahi ikehu mau pou mea pilikia, a me ka pinepine aole e he hiki.

He waiwai 'ana i kumumanaʻo o ka mea i ua loaʻa ka situs inversus ole wale i loko o kānaka akā, i waena o ka poeikohoia o ka holoholona honua, e like me e ikuwa ana. No laila, hometa, e like me ka rula, i ka poho iho, haika ma ka akau, akā, me ka alapine (frequency) o 1 a hiki i 10000 - 1 i 100000 poe kanaka, ka poe i ka poho iho, haika ana i ka hema.

Eia hou, ke aniani o ka maʻi o ka aina no ka hooulu ana i ka'ōuli, maikai loa. I loko nō o ka mea i ka Middle Ages Ua lōʻihi haule i loko o oblivion, he nui loa kanaka nō manaoio ia me ka situs inversus nā mea maʻi e komo mana, a me nā kūhelu 'epekema, ma ka huli, mau e enthusiastically hoʻopaʻa haʻawina i nā kumumea ma o na la ia i kekahi mau' mutation o ka genome.