"Octagam": aʻo no ka hoʻohana 'ana, nāʻikepili,ʻaoʻao' ole

Ua pili ia i ka lāʻau e hoʻokāʻoi aʻe ana i ka'ōnaehana paleʻea'ōnaehana, "Octagam". Rula e e hoʻomanaʻo aʻela ia keia mea he nui lāʻau, a me ka mea, ua hoʻolauna wale nō i loko o ka haukapila, pololei ma kuhikuhi. Hoʻohana 'ia e like me ka hope a me ka immunomodulatory lapaau.

Palapala hookuu i ka lāʻau a me kona haku mele 'ana

Ua ua hua mai i loko o ka palapala o ka pāʻoihana no infusion makaukau "Octagam" wale. Na Ke Kumu pili ia ia, a mea paha i OAXA study mua ana. Ke kākoʻo pāʻoihana Ua moakaka, me ka yellowish tinge. Ka lāʻau 'ua hua mai la i ka aniani hue 20, 50, 100, 200 ml, a i paa hou mai la me ka laholio pani a me ka Aluminum burnishing piha i loko o ka pepa pahu, kahi i hou i nā aʻo no ka hoʻohana' ia o ka ea-hei paa.

Ka medicament he ma 1 ml o ma ka liʻiliʻi 95% immunoglobulin G. ke anakahi Ua like no ka nui o ke kumuʻiʻo na i loko o kanaka koko wai koko. Additional 'ona i loko o ka haku mele' ana o ka lāʻau i:

• maltose;
• octoxynol;
• tributyl posapahate;
• wai no ka injections.

Ka lāʻau 'E ole pa ahau a kiola aku la i ke Map. Ua Ua waiho waho i ka wela o ka 2-8 ° C, i ka loaa ole o ke keiki.

Pharmacology a me ka pharmacokinetics

Uluwehi O "Octagam" (e manual ao mai e pili ana i contraindications, a hiki ka hopena o ka pono o ka ai ') e loli ai i ka kanaka'ōnaehana paleʻea'ōnaehana, a pili ia i immunoglobulins.

Ka lapaʻauʻia o kekahi hapa o ka immunoglobulin ka papa G, a paka nā mea'aʻaʻa i kela infectious keʻano o ka hanaʻana i loko o ke kino. I ka lāʻau 'ona i kakauia subclasses o ka immunoglobulin G,'ālike i kanaka wai koko,' oe a pau o kona waiwai a me nā 'ano. I ka hoike ana o ka lāʻau i loko o ke kino e hooponopono i ka ho'ēmi i kā pae o IgG,ʻo ia a hiki i ka maʻamau moku'āina. IgG nā lātoma aie i ka enzymatic a me ka Nine Inch waiū i ole loli. I ka ha awina o na nā mea'aʻaʻa ua hiki ke loa hoola.

No ka hoʻomäkaukau ' "Octagam" mea i oi aku mamua o 3% pīlali, i ka poe i koe ua manaoia no ka monomers a me dimers mea ma kahi o 90%.

A hiki aku oe e hana i ka hoʻopololeiʻia ana i ke koko o ka 3500 loa ola nā mea hāʻawi. Nā mea'aʻaʻa i a pau i loko o ka wai koko o kēia kanaka noho ana ma keia hoʻomākaukau ua hoʻololiʻia a koe oo kaila.

Ma hope o ka lāʻau 'aaieieno? I loko o ka aa koko immunoglobulin G koke komo ka systemic holo, a ua haawi ma waena o ka vascular makahiki a me ka wai koko. I ana i ka "Oktagama" ke hoʻomanawanui i ka ke ano hou i loko o 3-5 lā. Loko lapaau i 24-36 la lā. Ka hapa-ola mea okoa no ka kela mea keia mea, a hilinaʻi nui ma luna o ke ahonui o ka makahiki, degere o ka immunodeficiency. Immunoglobulin G 'ole' ē aʻe'ōnaehana paleʻea eiiieaenu i loaʻa kaʻeleu ke keʻena, luku ma ka reticuloendothelial nenoaiu.

I ka hoʻohana 'ana i "Octagam"?

Pili "Octagam" hope Inc, i ka wa e iniiaiie immunodeficiency syndromes, mua o nā mea a pau, he congenital hypogammaglobulinemia, agammaglobulinemia a me Wiskott-Aldrich maʻi pale. Kēia nā ee iaaanu aey unclassifiable immunodeficiency type, a hui immunodeficiencies.

Ke PAaIEN no ka lāʻau 'ua manao mau myeloma, lymphocytic maʻi palapala. Hoakaka ia ka lapaʻauʻia no nā mea maʻi me ka recurrent nā mea palahēhē, a me kaʻike, a HIV i keiki.

Ka lapaau Ua loaʻa kona hoʻohana i loko o therapies. Ia mea, ka mea, ua hoʻohana 'ia i loko o idiopathic thrombocytopenic purpura (ITP), pu ma ka māhuahua kamepiula o ke kahe ana ke koko. Nō hoʻi, i ka lāʻau ua hoʻohana 'ia ma muaʻoki kino e normalize platelet helu. Hoakaka ia ka lapaʻauʻia me Guillain-Barre maʻi pale. Ua lawelawe 'ana me ka PAaIEN no Kawasaki maʻi i loko o nā keiki a me nā mākua.

E hoʻohana i "Octagam" (hoʻohana palapala noi wehewehe i au mamuli o ka ano o ka hooponopono a me ka laʻau heluna o ka lāʻau) i loko o allogeneic iwi lolo transplantation.

Contraindications no infusions

Ua ao mai i ka mea i pono, e lawe i ka mooolelo contraindications mua hoʻohana "Octagam" hoʻomākaukau kuhikuhi. Mai hana i ka lapaau ana ma ke alo o ka hypersensitivity i kona constituent waiwai paha i homologous immunoglobulins.

Me ka palena mamao malama hoonoho i nā mea maʻi i ka lāʻau i mea obese. Ka mea, i ka predisposition e hoʻomōhala thrombosis. O ia hoʻi, ua contraindicated ina he mea he "ʻike, o ka hypertension," i ka maʻi o ka mimikō, maʻi o ka mea'ōnaehana mānowai koko'ōnaehana, haawi noho ole kalepa, mahuahua ma ka (viscosity) o ke koko.

A hiki i ka (viscosity) kiʻekiʻe o ka wai koko immunoglobulin, e komo i ke koko, e hoʻonāukiuki i ka pilikia o myocardial infarction, pulmonary embolism, hahauʻana, venous thrombosis.

Kaiapuni pono hoʻohana 'ia k ‰, nā mea maʻi me kaʻaʻa puʻuwai ka hoʻokō' ole a me nā mea maʻi me ka hypovolemia undergoing lapaau nephrotoxic konohiki. Inā he mea i huʻi mea, o ka immunoglobulin-ke kahuaʻaʻa puʻuwai maʻi, me ka "Oktagamom" Inc ua hoʻi i kāpiliʻia.

Nā mea maʻi me ka huʻiʻaʻa puʻuwai ole ma ka shape like pono me kanaka me ka thromboembolic complications o intravenous drip a me ka pahu kui, i ka lāʻau 'ua lawelawe lohi, a ma ka palena haʻahaʻa dala.

Ke ole o ka lāʻau i ka hapai keiki, a lactating nā wāhine i ole ua? Anoee, no laila, i ka manawa i hōʻike mai ka lapaʻauʻia e ke hoʻohana me ka lōʻihi mālama nui. I loko nō o kēia, i ka hana hōʻike ana i ka hoʻohana 'ana o immunoglobulins, aole ia i hoʻomaka ai i kekahi hopena maikaʻi' ole i hāpai keiki. Ka lāʻau i ole ia ma luna o ka fetus, a aole i pili i ke kamaiki ma ka makuwahine o ka waiū. Immunoglobulins, noho i loko o ka umauma ka waiu, mai i kekahi 'ino i ke keiki, a me na nā mea'aʻaʻa iloko o laila, wale he hoʻonui i ke kahua o ka ikaika e hoʻonele.

laʻau heluna

"Octagam" ka lāʻau ua lawelawe wale intravenously. Mua e hoʻomaka ana e lalana ana ia ia i ka lumi ana wela, i ka pāʻoihana hana e. I ka wai a pono e loa ka aniani moakaka, a i ole precipitate a me ka turbidity.

Kēlā me kēia lāʻau aaieieno? Ua kākau i loko o ka mōʻaukala o ka maʻi. Aia no hoi e lāʻau'ōhui ka helu a me ka inoa. Keia ua hana e hoʻoikaika i ka ka mālamaʻana o ka hoʻomanawanui ka kulana. Ka lāʻau 'koena ma hope o ka infusion, hiki ole ke hūnā a me ka pono e lukuia.

I ka loiloi mua ana o ka hoike sostvlyaet 0,01 i 0,02 ml / kg kino kaumaha i loko o kekahi minuke, a no laila, ma luna o ka hapalua o ka hora. i nā hiki ke hoomahuahua ia me ka maikai tolerability medicament ana i 0,12 ml / kg kino kaumaha no minuke.

I ka nui o ka lāʻau a me ka lōʻihi like 'ole o ka Inc e hooponoponoia ia mea, pākahi no kēlā me kēia hoʻomanawanui. Na mea a pau hilinaʻi nui ma luna o ka lapaʻau pane i loko o ka ua hoomanawanui, kona kulana a me kaʻike, o ka maʻi.

Hakahaka immunomodulating Inc ma iniiaiie immunodeficiency komo ai mahuahua dala o ka immunoglobulin G i 4.0-6.0 g. / L, ka mea i ana mamua i kēlā me kēia infusion. I mea e hoʻokō e like me ke aka, e hoopai auanei 3-6 mahina o ka nohoʻana. Ka loiloi mua mahele lāʻau aaieieno? O 0.4-0.8 g. / Kg. A laila i ka lāʻau 'ua lawelawe i nā mea maʻi i kēlā ekolu pule ma 0.2 g. / Kg. E kū ai i ka pale umauma hoʻokahi immunoglobulin 6.0 g. / L, pono e waiho i ka hoʻomanawanui i malama 0.2-0.8 g. / Kg o ka lāʻau. Once ka hoʻomanawanui hoike i ka maʻamau moku'āina, ka lāʻau mau ia e lawelawe na 2-4 pule, ma hope ana o ka lehulehu o ka immunoglobulin G i loko o ke koko. Kēia, e kōkuaʻoe koho i ka pono ai laʻau heluna.

Hakahaka ka lapaʻauʻia Inc ua mālama 'ia ma ka maʻi lymphocytic leukemia, i ae ai i ka haumāna hypogammaglobulinemia i loko loa palapala, i mau myeloma, e like me ia ma kaʻike, o "HIV maikaʻi" i na keiki me ka recurrent a me ka infectious keʻano o ka hanaʻana. Laʻau heluna, ke'ōlelo mai fluctuates puni 0.2-0.4 g. / Kg. Multiplicity o ka hoʻokomo 'ia' - kela 3-4 pule.

Iloko o ka iapaau ana o ka huʻi Episode o idiopathic thrombocytopenic purpura (ITP) ua hoʻohana 'ia i loko o ka laʻau heluna o ka lāʻau 0.8-1.0 g. / Kg wā lawelawe i ka lā mua. Inā pono, o ka hoʻohana hou 'ana o ka medicament hua ma 2-5 lā i loko o ka nui o ka 0,4 g. / Kg. Inā hihia o exacerbation o ka maʻi recur, ua lawelawe hou i ka waiʻona.

Guillain-Barre maʻi pale lapaʻau komo ai ma 0,4 g. / Kg o ka lāʻau no ka lā no ka 3-7 lā. Ma keia hihia, hoʻohana o ka lāʻau no nā keiki mea nui i kaupalena '.

Kawasaki maʻi i loko o nā keiki a me nā mākua ia me ka laʻau heluna o 1.6-2.0 g. / Kg. Ka lāʻau 'Ua lawelawe i loko o ka hookahi mahele lāʻau ma 2-5 lā. Ae hookahi lāʻau hoʻomanaʻo i loko o ka nui o 2.0 g. / Kg. Iloko o ka mākau alu lapaau o ka hoʻomanawanui ka poʻe me ka hoʻokomo 'ia' o "Oktagama" pono e hoʻohana aspirin.

Immunoglobulin ua hoʻohana 'ia ma hope o allogeneic iwi lolo transplantation hoomakaukau lapaau. Hoʻoponopono o ka lāʻau 'ano ua ālai' ka hanana o ka maʻiʻaʻai a me ka hooulu ana o ka maʻi pale o "pakuiia auanei lakou kū'ē puali". Ka laʻau heluna no kēlā me kēia hoomanawanui ua wae pākahi. ? Aeiiaiaiaaia e hoʻomaka mai i kekahi mahele lāʻau o 0.5 g. / Kg no hebedoma. ka pahu kui i ke kaʻina hana e hoʻomaka i ka hebedoma mua o ka mai ana mai hui, transplantation. Inc hoʻomau no ka ekolu mahina ma hope oʻoki kino. Inā he mea he ikaika aku nele i o immunoglobulins, ka lapaʻau hoʻohana i 0.5 g. / Kg kela mahina no ka lōʻihi me kā lākou maʻiʻo 'aʻole i hele mai hoʻi i mahana maʻamau.

ʻaoʻao waiwai

Ke kumuhana Ke i OAXA study mua ana ka lapaʻauʻia "Octagam" manual. Ka hooulu ana o kaʻaoʻao 'ole ia ka hoʻohana' ana i ka lāʻau 'hilinaʻi nui ma luna o ka mahele lāʻau a me ka uku o ka hooponopono.

Intravenous ka pahu kui a me ka lāʻau hiki i leukopenia, hemolysis a me reversible hemolytic anaemia. I ka lapaau ana o ka hiki io naoh o ka'ōnaehana paleʻea'ōnaehana, i hoʻohikiʻia ma o ka hoike ana o ka hypersensitivity. Ma pohihihi keia hihia e ku oe anaphylactoid a me anaphylactic reactions, puffiness o ka maka, angioedema.

HIV Inc i loko o nā keiki a me nā hana a nā maʻi pinepine ke kumu no headaches. He pohihihi keia lolo kāna hana o ke koko holo, excessive pīhoihoi, aseptic meningitis. Ka lāʻau 'hiki i headache, paresthesia a me ka vertigo.

Ma lapaʻau, aia no he pahiki o ka hanana o myocardial infarction. Aia i e ka mahuahua Kal a me ka tahikradiya. I kekahi manawa hoohihiaia cyanosis, hypotension a me ka thrombosis. Ua pohihihi keia circulatory insufficiency, hohonu aa koko thrombosis, hypertension.

Ka lāʻau 'hiki i ka adverse naoh ma ka aoao o ka naehana nenoaiu. Kēia naehana hanu ole, pulmonary edema, pokole o ka hanu. Ka hopena maikaʻi ka hopena i hoike ma ka pono o ka puʻu, bronchospasm, pulmonary embolism.

Ka iapaau ana hiki i nausea, ka luaʻi reflex, abdominalʻeha, diarrhea. Ma pohihihi keia hihia, he mea eczema, urticaria a me ka maneo. Ma kekahi hoʻomanawanuiʻana, ma hope o ka hoʻohana 'ana i ka lāʻau' ku ae la dermatitis, alopecia, a me ka pruritus.

Ua Ua kākaʻikahi malama reactions e like me kaʻeha ma ka hope wahi, myalgia a me ka arthralgia. More ma ka lapaʻau e hoʻoikaika iʻaʻa puʻuwai insufficiency, mahuahua lāʻau lapaʻau creatinine, i ko ke kuni, lōʻihi ka luhi, discomfort naoh ana ma ka ka pahu kui paena. Iwaena o infrequent adverse hanana malama ole,ʻeha i loko o ka pahu, flushing, malaise, lapuwale ia a me ka pyrexia. Ma pohihihi keia wahi, i hiki, nā mea maʻi i haʻahaʻa ke koko, anaphylactic kŰia.

Keʻano o ka hikiʻaoʻao loa i loko o nā mea maʻi, tolerated mua pono hooponopono o ka lāʻau. "Octagam" ke kumu no ka hoomahuahua i ake nā'ūhū a me ka monakō koko nā hoʻohui like me ka haʻawina keʻena hoʻokolohua koko.

Ka wā pono i koho mahele lāʻau kānāwai overdosing symptoms. He IeAUPIIe, IAa IO loli ka mālama i loko o ke kino, mahuahua koko (viscosity), i ka nānāʻana aku i loko o kanaka me ka hakuʻala maʻi, a me ka poʻeʻelemākule nā mea maʻi.

Ma nā mea a pau i ka luna hoopii, symptomatic kanaka ua paipai.

Cautions

Ka lāʻau 'Ua hiki ke emi i ka hopena o ke ola attenuated mea hoʻomaʻi vaccines no ka manawa o eono pule i na malama ekolu. E pale ia, oe e kali ma hope o ka noi ana o "Octagam" na malama ekolu o ka la hoomalolo. Ka lapaʻauʻia ho'ēmi i kā ka laulā o Waimānalo laʻau koʻokoʻo i loko o ka makahiki, no laila, ma mua o ka staging o keia vaccination E ke kulana kupono titerʻo Waimānalo nā mea'aʻaʻa.

Iapaau ana me keia k hiki i ka helu o kaʻaoʻao waiwai, no laila hoi e pono e hooko pololei me ka olelo no ka laʻau heluna a me ka hooponopono ana. Ma ka papa o ka Inc mea pono i na manawa a pau, e kanaka hoʻoponopono i ke ola o nā mea maʻi.

E hoomanawanui i ka poe i lawelawe intravenous immunoglobulin, e loaa kūpono hydration ma mua i ke kaʻina hana, e hoʻomaka ka mālamaʻana o ka mimi auaiaea a me ke koko creatinine. He pono e loa wehe i ka pili ana o ka "loop" diuretics.

Inā he mea io reactions e pono ai, e emi no ka uku o ka lāʻau hooponopono ole loa ka hoʻohana 'ia ana. Ke Inc hilinaʻi nui loa ma ka oolea a me ka ano o adverse hanana. Inā he mea he kŰia, ia mea pono e akoakoa ai i Anati-kŰia Inc, a e e hui me ka iapaau ana.

Loa pinepine ke kumu no adverse reactions kokololio mämä o ka hooponopono, o ka oi aku ma ka hypo- a me ka agammaglobulinemia a ana iniiaiie immunoglobulin. ʻaoʻao waiwai kānāwai ka wā laila 'o ia i ka hoomanawanui me ka immunoglobulin kekahi Hookah i kekahi lāʻau, a ina he wahi lihi iki o ka manawa i hala hope ka hope infusion.

Na Makuahine o kēia mau hoʻomanawanui iki mai (a me keia nā nā mea maʻi me HIV-maikaʻi kūlana haʻahaʻa) e halihaliia oia iwaho noke ma ka wā o ka infusion mua o ka hana, o ka oi aku i na hora mua ma hope o ka hana. E hoomanawanui i ka poe i oleʻaoʻao waiwai, ka mea e noho ma lalo o ke kauka o ka hooponopono ma hope o infusion "Oktagamom" ka mua 20 minuke.

Ma Inc E lawe maʻamau kaiapuni e ālai 'nā mea palahēhē i ka e hiki ia hoʻohana' ana i na laau i mai kanaka koko a me ka wai koko. O nā ke koho ana o nā mea hāʻawi kupono, ka mālamaʻana o kanaka, e lawelawe ana a me ka wai koko loko no kekahi mau hōʻailona o ka maʻiʻaʻai. Kēia kaʻina hana e hoʻohui i ana no ka inactivation / hoʻopau o nā mea hoʻomaʻi.

I loko nō a pau nā kaiapuni i loko o ka iapaau ana o ia ai ', ua hiki ole hookaawale ia i ka manawa kūpono o ka hoolilo ana o ka helu o ka Luna o nā mea palahēhē, nā mea hoʻomaʻi a me nā pathogens. A pau o ka mea ma luna ana hana ma ka manao paa o Hoamakeikekula nā mea hoʻomaʻi HIV, hepatitis B a me C. ka liʻiliʻi loa ka mea, ho oholo na nā moku halihali mokulele o ka parvovirus B19 a me ka gipatita A. lapaʻau hana o ka lapaʻau konohiki i loaʻa kanaka immunoglobulin paipai ia parvovirus B19 a me ka hepatitis A i loko o ka iapaau ana o ai 'ole i hikiʻikepili. O ka nui i loko o antiviral maluhia o ke alo i loko o ka lāʻau lapaʻau huahana like nā mea'aʻaʻa.

Iloko o ka hooholo ana o ka pākōlea papa passively hoololiia nā mea'aʻaʻa i loko o ka hoʻomanawanui ka koko e haawi wahahee hualoaʻa ka wā e hali ana mai serologic ho'āʻo ma. Maltose na i loko o ka la hoomalolo, ua hiki no wahahee paha ka nānaina i ke koko monakō koko pae.

Hoʻokāʻoi hana ana i loko o ke koko monakō koko lehulehu malama i wehe 'ana i ka lāʻau, mai ka meaola ole umikumamalima hola ma hope o kona panina. Ma keia hihia, he mea he manawa kūpono no paʻewa ai manao insulina mahele lāʻau e hiki hoʻonāukiuki hypoglycemia. Nolaila, wale glyukozospetsificheskie epekema ka 'ike i ka nui o ka monakō koko i loko o ke koko e e hoʻohana' ia ma ka iapaau ana o "0ktagamom". Ho'āʻo He poho no ka mālamaʻana i ke koko kō e e hiki ke hooholo i kēia aiao i loko o nā mea maʻi lawe lapaʻauʻia me ka maltose.

Inā i pau, a laila, 'ae' e hoahu ai ' "Octagam" (50 ml a me 100 ml) i wela mai ai i + 25 ° C no na malama ekolu ole kiʻekiʻe waiho ia i loko o ka Pahu Hau. Ua hanaʻole no i hoakaka ia manawa, pono e luku aku i ka lāʻau.

Ka lapaʻauʻia aʻole e pili mai ka hiki, e kipaku aku a me ka hana 'ana i noi aku i nānā' nā kapuwaʻiʻehā, a kokololio psychomotor reactions.

Uluwehi O "Octagam": counterparts

Kēia lapaau i ka helu o ka analogues e hiki e puku i aku la ia ia ma ka hihia o ka nele, ia mea:

• "Biaven VI."
• "Veegum-ʻoihana kālā."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Gamma Globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

Lūkini ae pani ai, ua nui ho'ēmi ma mua o kā lākou mau haole counterparts. Ma kekahi hihia, i kēia mau ai 'a pau i loa lawa eʻohi mai, a pono e UAIAaIN wale ma kekahi kauka, ma muli o ka hoʻomanawanui ka kulana.

"Octagam" Medicine: kuai

Ke kumu o ka lāʻau Ua kiʻekiʻe. Ua hiki ke kuai no 9,5-12 tausani rubles a me 50 ml o ka lāʻau "Octagam". 100 ml Price mea a puni 20-24 tausani rubles.

Na manao o ka hoʻomanawanui iki mai a me ka lapaau

Uluwehi O "Octagam" i hōʻike manaʻo ka hapanui maikaʻi. No mahalo 'kona mea e like ai kanaka, ka mea ana i kokua e loaa me ka immunodeficiency a me Guillain-Barre maʻi pale. Ua Ua pinepine hoʻohana no ka poʻe me kōkua iā ia, kōkua ma muli o kā lākou ola. He hoao ia e mana i ka maʻi lymphocytic leukemia, myasthenia gravis. Women hoʻohana 'ia k ‰ e lilo i hapai keiki, a hānau mai he keiki.

Ka hapa nui o na nā mea maʻi i hauʻoli i ka lilo o ka lāʻau, ka mea, e hoailona oukou ia ia mea paakiki e kuai i keʻena kūʻai lāʻau lapaʻau. Kekahi kapa ia i ka nawaliwali, headache, a me ka mau malaise.

Kauka e olelo aku i ka mea, o ka la hoomalolo maemae, ka mea, ua pono ke kemu ma ke kino, a like wahi lulu immunoglobulins paha emi i ka i allergies.